Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

A large body of data exists demonstrating that neonatal Fc receptor (FcRn) binding of an IgG via its Fc CH2-CH3 interface trends with the pharmacokinetics (PK) of IgG. We have observed that PK of IgG molecules vary widely, even when they share identical Fc domains. This led us to hypothesize that do...

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Autores principales: Piche-Nicholas, Nicole M., Avery, Lindsay B., King, Amy C., Kavosi, Mania, Wang, Mengmeng, O'Hara, Denise M., Tchistiakova, Lioudmila, Katragadda, Madan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800364/
https://www.ncbi.nlm.nih.gov/pubmed/28991504
http://dx.doi.org/10.1080/19420862.2017.1389355

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