Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets

Transgenic animal platforms for the discovery of human monoclonal antibodies have been developed in mice, rats, rabbits and cows. The immune response to human proteins is limited in these animals by their tolerance to mammalian-conserved epitopes. To expand the range of epitopes that are accessible,...

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Detalles Bibliográficos
Autores principales: Ching, Kathryn H., Collarini, Ellen J., Abdiche, Yasmina N., Bedinger, Daniel, Pedersen, Darlene, Izquierdo, Shelley, Harriman, Rian, Zhu, Lei, Etches, Robert J., van de Lavoir, Marie-Cecile, Harriman, William D., Leighton, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800366/
https://www.ncbi.nlm.nih.gov/pubmed/29035625
http://dx.doi.org/10.1080/19420862.2017.1386825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800366/
https://www.ncbi.nlm.nih.gov/pubmed/29035625
http://dx.doi.org/10.1080/19420862.2017.1386825

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