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Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets
Transgenic animal platforms for the discovery of human monoclonal antibodies have been developed in mice, rats, rabbits and cows. The immune response to human proteins is limited in these animals by their tolerance to mammalian-conserved epitopes. To expand the range of epitopes that are accessible,...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800366/ https://www.ncbi.nlm.nih.gov/pubmed/29035625 http://dx.doi.org/10.1080/19420862.2017.1386825 |