Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration

BACKGROUND: Metabolic reprogramming is shaped to support specific cell functions since cellular metabolism controls the final outcome of immune response. Multiple sclerosis (MS) is an autoimmune disease resulting from loss of immune tolerance against central nervous system (CNS) myelin. Metabolic al...

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Detalles Bibliográficos
Autores principales: La Rocca, Claudia, Carbone, Fortunata, De Rosa, Veronica, Colamatteo, Alessandra, Galgani, Mario, Perna, Francesco, Lanzillo, Roberta, Brescia Morra, Vincenzo, Orefice, Giuseppe, Cerillo, Ilaria, Florio, Ciro, Maniscalco, Giorgia Teresa, Salvetti, Marco, Centonze, Diego, Uccelli, Antonio, Longobardi, Salvatore, Visconti, Andrea, Matarese, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800394/
https://www.ncbi.nlm.nih.gov/pubmed/29132538
http://dx.doi.org/10.1016/j.metabol.2017.08.011

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