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Effects of Vitamin D Deficiency on Incidence Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis

INTRODUCTION: Proper nutrition is important for overall health, and it reduces healthcare costs associated with malnutrition. Many studies have investigated vitamin D deficiency and its role in gestational diabetes and controversial data have reported. A comprehensive consideration of articles in th...

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Autores principales: Amraei, Mansour, Mohamadpour, Safoura, Sayehmiri, Kourosh, Mousavi, Seyedeh Fatemeh, Shirzadpour, Ehsan, Moayeri, Ardeshir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800395/
https://www.ncbi.nlm.nih.gov/pubmed/29449829
http://dx.doi.org/10.3389/fendo.2018.00007
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author Amraei, Mansour
Mohamadpour, Safoura
Sayehmiri, Kourosh
Mousavi, Seyedeh Fatemeh
Shirzadpour, Ehsan
Moayeri, Ardeshir
author_facet Amraei, Mansour
Mohamadpour, Safoura
Sayehmiri, Kourosh
Mousavi, Seyedeh Fatemeh
Shirzadpour, Ehsan
Moayeri, Ardeshir
author_sort Amraei, Mansour
collection PubMed
description INTRODUCTION: Proper nutrition is important for overall health, and it reduces healthcare costs associated with malnutrition. Many studies have investigated vitamin D deficiency and its role in gestational diabetes and controversial data have reported. A comprehensive consideration of articles in this field provides the possibility of a general study of this relationship. This meta-analysis is an evaluation of the relationship between vitamin D deficiency and gestational diabetes. MATERIAL AND METHODS: Different databases (such as PubMed, Science Information Institute, EmBase, Scopus, and the Cochrane Library) were searched for studies and eligible English articles published before February 2017 that have reported the risk of gestational diabetes in relation to vitamin D deficiency. This relationship was measured using odds ratios (ORs) with a confidence interval (CI) of 95%. The influence of each study was measured through sensitivity analysis. Funnel plots, Egger regression tests, and the Begg–Mazumdar correlation test were used to determine bias or publication bias. STATA (version 11.2) was used for all analyses. RESULTS: Twenty-six studies were selected as eligible for this research and included in the final analysis. In general, vitamin D deficiency among mothers may be related to an increased risk of gestational diabetes (OR = 1.18; 95% CI, 1.01–1.35; p < 0.001). The serum level of 25(OH)D is less meaningful in people with gestational diabetes than in those who have normal glucose tolerance. Subgroup analysis showed that the results concerning this association may vary with study design but do not change with country of origin. CONCLUSION: Some evidence has shown that vitamin D deficiency may increase the risk of gestational diabetes.
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spelling pubmed-58003952018-02-15 Effects of Vitamin D Deficiency on Incidence Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis Amraei, Mansour Mohamadpour, Safoura Sayehmiri, Kourosh Mousavi, Seyedeh Fatemeh Shirzadpour, Ehsan Moayeri, Ardeshir Front Endocrinol (Lausanne) Endocrinology INTRODUCTION: Proper nutrition is important for overall health, and it reduces healthcare costs associated with malnutrition. Many studies have investigated vitamin D deficiency and its role in gestational diabetes and controversial data have reported. A comprehensive consideration of articles in this field provides the possibility of a general study of this relationship. This meta-analysis is an evaluation of the relationship between vitamin D deficiency and gestational diabetes. MATERIAL AND METHODS: Different databases (such as PubMed, Science Information Institute, EmBase, Scopus, and the Cochrane Library) were searched for studies and eligible English articles published before February 2017 that have reported the risk of gestational diabetes in relation to vitamin D deficiency. This relationship was measured using odds ratios (ORs) with a confidence interval (CI) of 95%. The influence of each study was measured through sensitivity analysis. Funnel plots, Egger regression tests, and the Begg–Mazumdar correlation test were used to determine bias or publication bias. STATA (version 11.2) was used for all analyses. RESULTS: Twenty-six studies were selected as eligible for this research and included in the final analysis. In general, vitamin D deficiency among mothers may be related to an increased risk of gestational diabetes (OR = 1.18; 95% CI, 1.01–1.35; p < 0.001). The serum level of 25(OH)D is less meaningful in people with gestational diabetes than in those who have normal glucose tolerance. Subgroup analysis showed that the results concerning this association may vary with study design but do not change with country of origin. CONCLUSION: Some evidence has shown that vitamin D deficiency may increase the risk of gestational diabetes. Frontiers Media S.A. 2018-02-01 /pmc/articles/PMC5800395/ /pubmed/29449829 http://dx.doi.org/10.3389/fendo.2018.00007 Text en Copyright © 2018 Amraei, Mohamadpour, Sayehmiri, Mousavi, Shirzadpour and Moayeri. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Amraei, Mansour
Mohamadpour, Safoura
Sayehmiri, Kourosh
Mousavi, Seyedeh Fatemeh
Shirzadpour, Ehsan
Moayeri, Ardeshir
Effects of Vitamin D Deficiency on Incidence Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis
title Effects of Vitamin D Deficiency on Incidence Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis
title_full Effects of Vitamin D Deficiency on Incidence Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis
title_fullStr Effects of Vitamin D Deficiency on Incidence Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis
title_full_unstemmed Effects of Vitamin D Deficiency on Incidence Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis
title_short Effects of Vitamin D Deficiency on Incidence Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis
title_sort effects of vitamin d deficiency on incidence risk of gestational diabetes mellitus: a systematic review and meta-analysis
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800395/
https://www.ncbi.nlm.nih.gov/pubmed/29449829
http://dx.doi.org/10.3389/fendo.2018.00007
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