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Establishing Reference Ranges of Hematological Parameters from Malian Healthy Adults

INTRODUCTION: Measurement of immuno-hematological parameters has been historically helpful in the diagnosis and treatment monitoring of many infectious diseases and cancers. However, these parameters have not yet been established in many developing countries where patient care strongly relies on suc...

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Autores principales: Kone, B, Maiga, M, Baya, B, Sarro, YDS, Coulibaly, N, Kone, A, Diarra, B, Sanogo, M, Togo, ACG, Goita, D, Dembele, M, Polis, MA, Warfield, J, Belson, M, Dao, S, Orsega, S, Murphy, RL, Diallo, S, Siddiqui, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800422/
https://www.ncbi.nlm.nih.gov/pubmed/29423342
http://dx.doi.org/10.4172/2165-7831.1000154
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author Kone, B
Maiga, M
Baya, B
Sarro, YDS
Coulibaly, N
Kone, A
Diarra, B
Sanogo, M
Togo, ACG
Goita, D
Dembele, M
Polis, MA
Warfield, J
Belson, M
Dao, S
Orsega, S
Murphy, RL
Diallo, S
Siddiqui, S
author_facet Kone, B
Maiga, M
Baya, B
Sarro, YDS
Coulibaly, N
Kone, A
Diarra, B
Sanogo, M
Togo, ACG
Goita, D
Dembele, M
Polis, MA
Warfield, J
Belson, M
Dao, S
Orsega, S
Murphy, RL
Diallo, S
Siddiqui, S
author_sort Kone, B
collection PubMed
description INTRODUCTION: Measurement of immuno-hematological parameters has been historically helpful in the diagnosis and treatment monitoring of many infectious diseases and cancers. However, these parameters have not yet been established in many developing countries where patient care strongly relies on such low-cost tests. This study describes the immuno-hematological parameter ranges for Malian healthy adults. METHODS: A cross sectional study was conducted from August 2004 to May 2013. We included 213 healthy volunteers (173 male and 40 female), aged between 18–59 years. Median, 2.5 and 97.5 percentile ranges for each immuno-hematological parameter are presented. RESULTS: In our study population, the hematological parameters’ ranges were mostly different to the universal established ranges. We found in our population a Median white blood cell (WBC) count of 5200 cells/μL [3237.5–11900], Red Blood Cell (RBC) count of 4.94 10^6 [3.56–6.17], hemoglobin (Hb) of 14.2 g/dL [12.2–17.38], platelet count (Plt) of 275 10^3/μL [145.4–614.4], lymphocytes 2050/μL [1200–3800], neutrophils 2200/μL [1040–6220]; monocytes 200/μL [100–660]; eosinophils 131/μL [0–1026]; CD4 902 cells/μL [444–1669] and CD8 485 cells/μL [0–1272]. We found significant gender differences in RBC, Hb level and MPV. However, RBC and Hb were higher in males median values compared to females (median values) (p<0.001), whereas the Mean platelet volume lower values (MPV) in males than females (P<0.047). The hemoglobin level for some West African countries (Mali, Burkina Faso, Togo, and Nigeria) ranged from 13.5 to 15.1 g/dL for males and 12 to 13 g/dL for females. However in East and Southern Africa, the values were anywhere from 14.1 to 16.1 for males and 11.2 to 14.4 for females. CONCLUSION: Our data may help physicians to better define hematological abnormalities in patients. They may also be used to define new “normal hematological values” in Malian population or in the whole West African population.
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spelling pubmed-58004222018-02-06 Establishing Reference Ranges of Hematological Parameters from Malian Healthy Adults Kone, B Maiga, M Baya, B Sarro, YDS Coulibaly, N Kone, A Diarra, B Sanogo, M Togo, ACG Goita, D Dembele, M Polis, MA Warfield, J Belson, M Dao, S Orsega, S Murphy, RL Diallo, S Siddiqui, S J Blood Lymph Article INTRODUCTION: Measurement of immuno-hematological parameters has been historically helpful in the diagnosis and treatment monitoring of many infectious diseases and cancers. However, these parameters have not yet been established in many developing countries where patient care strongly relies on such low-cost tests. This study describes the immuno-hematological parameter ranges for Malian healthy adults. METHODS: A cross sectional study was conducted from August 2004 to May 2013. We included 213 healthy volunteers (173 male and 40 female), aged between 18–59 years. Median, 2.5 and 97.5 percentile ranges for each immuno-hematological parameter are presented. RESULTS: In our study population, the hematological parameters’ ranges were mostly different to the universal established ranges. We found in our population a Median white blood cell (WBC) count of 5200 cells/μL [3237.5–11900], Red Blood Cell (RBC) count of 4.94 10^6 [3.56–6.17], hemoglobin (Hb) of 14.2 g/dL [12.2–17.38], platelet count (Plt) of 275 10^3/μL [145.4–614.4], lymphocytes 2050/μL [1200–3800], neutrophils 2200/μL [1040–6220]; monocytes 200/μL [100–660]; eosinophils 131/μL [0–1026]; CD4 902 cells/μL [444–1669] and CD8 485 cells/μL [0–1272]. We found significant gender differences in RBC, Hb level and MPV. However, RBC and Hb were higher in males median values compared to females (median values) (p<0.001), whereas the Mean platelet volume lower values (MPV) in males than females (P<0.047). The hemoglobin level for some West African countries (Mali, Burkina Faso, Togo, and Nigeria) ranged from 13.5 to 15.1 g/dL for males and 12 to 13 g/dL for females. However in East and Southern Africa, the values were anywhere from 14.1 to 16.1 for males and 11.2 to 14.4 for females. CONCLUSION: Our data may help physicians to better define hematological abnormalities in patients. They may also be used to define new “normal hematological values” in Malian population or in the whole West African population. 2017-03-15 2017 /pmc/articles/PMC5800422/ /pubmed/29423342 http://dx.doi.org/10.4172/2165-7831.1000154 Text en http://creativecommons.org/licenses/by/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Kone, B
Maiga, M
Baya, B
Sarro, YDS
Coulibaly, N
Kone, A
Diarra, B
Sanogo, M
Togo, ACG
Goita, D
Dembele, M
Polis, MA
Warfield, J
Belson, M
Dao, S
Orsega, S
Murphy, RL
Diallo, S
Siddiqui, S
Establishing Reference Ranges of Hematological Parameters from Malian Healthy Adults
title Establishing Reference Ranges of Hematological Parameters from Malian Healthy Adults
title_full Establishing Reference Ranges of Hematological Parameters from Malian Healthy Adults
title_fullStr Establishing Reference Ranges of Hematological Parameters from Malian Healthy Adults
title_full_unstemmed Establishing Reference Ranges of Hematological Parameters from Malian Healthy Adults
title_short Establishing Reference Ranges of Hematological Parameters from Malian Healthy Adults
title_sort establishing reference ranges of hematological parameters from malian healthy adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800422/
https://www.ncbi.nlm.nih.gov/pubmed/29423342
http://dx.doi.org/10.4172/2165-7831.1000154
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