Efficacy of PI3K/AKT/mTOR pathway inhibitors for the treatment of advanced solid cancers: A literature-based meta-analysis of 46 randomised control trials

BACKGROUND: The phosphatidylinositol-3- kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway (PI3K/AKT/mTOR pathway) plays a key role in cancer. We performed this meta-analysis to assess the clinical effect of using PI3K/AKT/mTOR pathway inhibitors on advanced solid tumours. METHODS: All t...

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Detalles Bibliográficos
Autores principales: Li, Xuan, Dai, Danian, Chen, Bo, Tang, Hailin, Xie, Xiaoming, Wei, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800666/
https://www.ncbi.nlm.nih.gov/pubmed/29408858
http://dx.doi.org/10.1371/journal.pone.0192464

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