CRL4 antagonizes SCF(Fbxo7)-mediated turnover of cereblon and BK channel to regulate learning and memory

Intellectual disability (ID), one of the most common human developmental disorders, can be caused by genetic mutations in Cullin 4B (Cul4B) and cereblon (CRBN). CRBN is a substrate receptor for the Cul4A/B-DDB1 ubiquitin ligase (CRL4) and can target voltage- and calcium-activated BK channel for ER r...

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Detalles Bibliográficos
Autores principales: Song, Tianyu, Liang, Shenghui, Liu, Jiye, Zhang, Tingyue, Yin, Yifei, Geng, Chenlu, Gao, Shaobing, Feng, Yan, Xu, Hao, Guo, Dongqing, Roberts, Amanda, Gu, Yuchun, Cang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800687/
https://www.ncbi.nlm.nih.gov/pubmed/29370161
http://dx.doi.org/10.1371/journal.pgen.1007165

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