Rewired Notch/p53 by Numb’ing Mdm2

Although numerous pathways are known to control the tumor suppressor protein p53, coordinated regulation of the p53–Notch axis by Numb may have an even more remarkable impact. In this issue, Colaluca at al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201709092) reveal an unexpected role of a ne...

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Detalles Bibliográficos
Autores principales: Kim, Hyungsoo, Ronai, Ze’ev A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2018
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800819/
https://www.ncbi.nlm.nih.gov/pubmed/29339436
http://dx.doi.org/10.1083/jcb.201712007
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author Kim, Hyungsoo
Ronai, Ze’ev A.
author_facet Kim, Hyungsoo
Ronai, Ze’ev A.
author_sort Kim, Hyungsoo
collection PubMed
description Although numerous pathways are known to control the tumor suppressor protein p53, coordinated regulation of the p53–Notch axis by Numb may have an even more remarkable impact. In this issue, Colaluca at al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201709092) reveal an unexpected role of a newly characterized Numb splice variant in the regulation of p53, which may have significant implications for therapeutic intervention in breast cancer.
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spelling pubmed-58008192018-08-05 Rewired Notch/p53 by Numb’ing Mdm2 Kim, Hyungsoo Ronai, Ze’ev A. J Cell Biol Commentaries Although numerous pathways are known to control the tumor suppressor protein p53, coordinated regulation of the p53–Notch axis by Numb may have an even more remarkable impact. In this issue, Colaluca at al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201709092) reveal an unexpected role of a newly characterized Numb splice variant in the regulation of p53, which may have significant implications for therapeutic intervention in breast cancer. The Rockefeller University Press 2018-02-05 /pmc/articles/PMC5800819/ /pubmed/29339436 http://dx.doi.org/10.1083/jcb.201712007 Text en © 2018 Kim and Ronai http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Kim, Hyungsoo
Ronai, Ze’ev A.
Rewired Notch/p53 by Numb’ing Mdm2
title Rewired Notch/p53 by Numb’ing Mdm2
title_full Rewired Notch/p53 by Numb’ing Mdm2
title_fullStr Rewired Notch/p53 by Numb’ing Mdm2
title_full_unstemmed Rewired Notch/p53 by Numb’ing Mdm2
title_short Rewired Notch/p53 by Numb’ing Mdm2
title_sort rewired notch/p53 by numb’ing mdm2
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800819/
https://www.ncbi.nlm.nih.gov/pubmed/29339436
http://dx.doi.org/10.1083/jcb.201712007
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