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R-spondins can potentiate WNT signaling without LGRs

The WNT signaling pathway regulates patterning and morphogenesis during development and promotes tissue renewal and regeneration in adults. The R-spondin (RSPO) family of four secreted proteins, RSPO1-4, amplifies target cell sensitivity to WNT ligands by increasing WNT receptor levels. Leucine-rich...

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Detalles Bibliográficos
Autores principales:	Lebensohn, Andres M, Rohatgi, Rajat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800842/ https://www.ncbi.nlm.nih.gov/pubmed/29405118 http://dx.doi.org/10.7554/eLife.33126

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