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A novel suicide gene therapy for the treatment of p16(Ink4a)-overexpressing tumors
p16(Ink4a) is a potent cell cycle inhibitor engaged to support cell cycle arrest during cellular senescence. However, in tumors carrying mutations in key downstream effectors, p16(Ink4a) is highly expressed but fails to block cell proliferation. p16(Ink4a)-overexpressing tumor cells are highly aggre...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800901/ https://www.ncbi.nlm.nih.gov/pubmed/29484109 http://dx.doi.org/10.18632/oncotarget.23752 |