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CISH promoter polymorphism effects on T cell cytokine receptor signaling and type 1 diabetes susceptibility

BACKGROUND: Impaired regulatory T cell immunity plays a central role in the development of type 1 diabetes (T1D). Interleukin-2 receptor (IL-2R) signaling is essential for regulatory T cells (T(REG)), and cytokine-inducible SH2-containing protein (CIS) regulates IL-2R signaling as a feedback inhibit...

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Detalles Bibliográficos
Autores principales:	Seyfarth, Julia, Ahlert, Heinz, Rosenbauer, Joachim, Baechle, Christina, Roden, Michael, Holl, Reinhard W., Mayatepek, Ertan, Meissner, Thomas, Jacobsen, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801137/ https://www.ncbi.nlm.nih.gov/pubmed/29411179 http://dx.doi.org/10.1186/s40348-018-0080-7

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