Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain

Zika virus (ZIKV) infection during early pregnancy can cause microcephaly and associated defects at birth, but whether it can induce neurologic sequelae that appear later in life remains unclear. Using a model of the developing brain based on embryonic stem cell-derived brain organoids, we studied t...

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Detalles Bibliográficos
Autores principales: Janssens, Sylvie, Schotsaert, Michael, Karnik, Rahul, Balasubramaniam, Vinod, Dejosez, Marion, Meissner, Alexander, García-Sastre, Adolfo, Zwaka, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801341/
https://www.ncbi.nlm.nih.gov/pubmed/29435496
http://dx.doi.org/10.1128/mSystems.00219-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801341/
https://www.ncbi.nlm.nih.gov/pubmed/29435496
http://dx.doi.org/10.1128/mSystems.00219-17

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