Improved survival rate after myocardial infarction using an inducible cholesterol efflux (iCE) peptide: FAMP

BACKGROUND: There have been no previous reports that apolipoprotein (apo) A-I mimetic peptide improves survival rate after myocardial infarction (MI). METHOD AND RESULTS: Male C57Bl/6J mice were subjected to left coronary artery permanent ligation as a model of MI. We synthesized a novel 24-amino ac...

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Detalles Bibliográficos
Autores principales: Yahiro, Eiji, Uehara, Yoshinari, Kawachi, Emi, Ando, Setsuko, Miura, Shin-ichiro, Saku, Keijiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801440/
https://www.ncbi.nlm.nih.gov/pubmed/29450188
http://dx.doi.org/10.1016/j.ijchv.2014.05.005
Descripción
Sumario:BACKGROUND: There have been no previous reports that apolipoprotein (apo) A-I mimetic peptide improves survival rate after myocardial infarction (MI). METHOD AND RESULTS: Male C57Bl/6J mice were subjected to left coronary artery permanent ligation as a model of MI. We synthesized a novel 24-amino acid apoA-I mimetic peptide-type5 (FAMP5), which potently removes cholesterol via specific ATP-binding cassette transporter A1 (ABCA1). FAMP5 was associated with a significantly improved survival rate by protecting against cardiac rupture compared to the control. mRNA levels for eNOS, Gata-4, CTGF and ANP were significantly increased in the hearts of the FAMP5-treated group, while that for MCP-1 decreased. CONCLUSION: This is the first report that high-density lipoprotein (HDL) therapy with FAMP5 improved the survival rate after MI.

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