The Art of War: harnessing the epigenome against cancer

Histone chaperones are indispensable regulators of chromatin structure and function. Recent work has shown that they are frequently mis-regulated in cancer, which can have profound consequences on tumor growth and survival. Here, we focus on chaperones for the essential H3 histone variants H3.3 and...

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Detalles Bibliográficos
Autores principales: Nye, Jonathan, Melters, Daniël P., Dalal, Yamini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801563/
https://www.ncbi.nlm.nih.gov/pubmed/29479426
http://dx.doi.org/10.12688/f1000research.12833.1
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author Nye, Jonathan
Melters, Daniël P.
Dalal, Yamini
author_facet Nye, Jonathan
Melters, Daniël P.
Dalal, Yamini
author_sort Nye, Jonathan
collection PubMed
description Histone chaperones are indispensable regulators of chromatin structure and function. Recent work has shown that they are frequently mis-regulated in cancer, which can have profound consequences on tumor growth and survival. Here, we focus on chaperones for the essential H3 histone variants H3.3 and CENP-A, specifically HIRA, DAXX/ATRX, DEK, and HJURP. This review summarizes recent studies elucidating their roles in regulating chromatin and discusses how cancer-specific chromatin interactions can be exploited to target cancer cells.
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spelling pubmed-58015632018-02-22 The Art of War: harnessing the epigenome against cancer Nye, Jonathan Melters, Daniël P. Dalal, Yamini F1000Res Review Histone chaperones are indispensable regulators of chromatin structure and function. Recent work has shown that they are frequently mis-regulated in cancer, which can have profound consequences on tumor growth and survival. Here, we focus on chaperones for the essential H3 histone variants H3.3 and CENP-A, specifically HIRA, DAXX/ATRX, DEK, and HJURP. This review summarizes recent studies elucidating their roles in regulating chromatin and discusses how cancer-specific chromatin interactions can be exploited to target cancer cells. F1000 Research Limited 2018-02-02 /pmc/articles/PMC5801563/ /pubmed/29479426 http://dx.doi.org/10.12688/f1000research.12833.1 Text en Copyright: © 2018 Nye J et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The author(s) is/are employees of the US Government and therefore domestic copyright protection in USA does not apply to this work. The work may be protected under the copyright laws of other jurisdictions when used in those jurisdictions.
spellingShingle Review
Nye, Jonathan
Melters, Daniël P.
Dalal, Yamini
The Art of War: harnessing the epigenome against cancer
title The Art of War: harnessing the epigenome against cancer
title_full The Art of War: harnessing the epigenome against cancer
title_fullStr The Art of War: harnessing the epigenome against cancer
title_full_unstemmed The Art of War: harnessing the epigenome against cancer
title_short The Art of War: harnessing the epigenome against cancer
title_sort art of war: harnessing the epigenome against cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801563/
https://www.ncbi.nlm.nih.gov/pubmed/29479426
http://dx.doi.org/10.12688/f1000research.12833.1
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