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Arsenic trioxide attenuates STAT-3 activity and epithelial-mesenchymal transition through induction of SHP-1 in gastric cancer cells

BACKGROUND: We investigated the effect of arsenic trioxide (ATO) for inhibition of signal transducer and activator of transcription 3 (STAT3) and epithelial-mesenchymal transition (EMT) in gastric cancer cells, and the role of SH2 domain-containing phosphatase-1 (SHP-1) during this process. METHODS:...

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Detalles Bibliográficos
Autores principales:	Kim, Sung Ho, Yoo, Hyo Soon, Joo, Moon Kyung, Kim, Taehyun, Park, Jong-Jae, Lee, Beom Jae, Chun, Hoon Jai, Lee, Sang Woo, Bak, Young-Tae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801683/ https://www.ncbi.nlm.nih.gov/pubmed/29409467 http://dx.doi.org/10.1186/s12885-018-4071-9

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