Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: a case report

BACKGROUND: Cancer vaccines can effectively establish clinically relevant tumor immunity. Novel sequencing approaches rapidly identify the mutational fingerprint of tumors, thus allowing to generate personalized tumor vaccines within a few weeks from diagnosis. Here, we report the case of a 62-year-...

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Detalles Bibliográficos
Autores principales: Sonntag, Katja, Hashimoto, Hisayoshi, Eyrich, Matthias, Menzel, Moritz, Schubach, Max, Döcker, Dennis, Battke, Florian, Courage, Carolina, Lambertz, Helmut, Handgretinger, Rupert, Biskup, Saskia, Schilbach, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801813/
https://www.ncbi.nlm.nih.gov/pubmed/29409514
http://dx.doi.org/10.1186/s12967-018-1382-1

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