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Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β
BACKGROUND: Dietary bioactive compounds capable of improving metabolic profiles would be of great value, especially for overweight individuals undergoing a caloric restriction (CR) regimen. Curcumin (Cur), a possible anti-obesity compound, and piperine (Pip), a plausible enhancer of Cur’s bioavailab...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801844/ https://www.ncbi.nlm.nih.gov/pubmed/29445415 http://dx.doi.org/10.1186/s12986-018-0250-6 |
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author | Miyazawa, Taiki Nakagawa, Kiyotaka Kim, Sharon H. Thomas, Michael J. Paul, Ligi Zingg, Jean-Marc Dolnikowski, Gregory G. Roberts, Susan B. Kimura, Fumiko Miyazawa, Teruo Azzi, Angelo Meydani, Mohsen |
author_facet | Miyazawa, Taiki Nakagawa, Kiyotaka Kim, Sharon H. Thomas, Michael J. Paul, Ligi Zingg, Jean-Marc Dolnikowski, Gregory G. Roberts, Susan B. Kimura, Fumiko Miyazawa, Teruo Azzi, Angelo Meydani, Mohsen |
author_sort | Miyazawa, Taiki |
collection | PubMed |
description | BACKGROUND: Dietary bioactive compounds capable of improving metabolic profiles would be of great value, especially for overweight individuals undergoing a caloric restriction (CR) regimen. Curcumin (Cur), a possible anti-obesity compound, and piperine (Pip), a plausible enhancer of Cur’s bioavailability and efficacy, may be candidate agents for controlling body fat, metabolism and low grade inflammation. METHODS: 47 eight-week-old male C57BL/6 mice were fed a high fat diet (HFD) for 23 weeks to induce obesity. Then, mice were divided into 5 groups. Group 1 continued on HFD ad libitum. The other 4 groups underwent CR (reduced 10% HFD intake for 10 weeks, 20% for 20 weeks) with Cur, Pip, Cur + Pip or none of these. Percent body fat, plasma inflammatory markers associated with obesity (interferon (IFN)-γ, interleukin (IL)-10, IL-12 p70, IL-1β, IL-6 and KC/GRO), plasma Cur metabolites and liver telomere length were measured. RESULTS: Compared to the other groups, obese mice who underwent CR and received Cur + Pip in their diet lost more fat and had significantly lower IL-1β and KC/GRO. Tandem mass spectrometry analysis of plasma from obese mice under CR showed no difference in Cur metabolite levels between groups supplemented with Cur alone or combined with Pip. However, plasma IL-1β levels were inversely correlated with curcumin glucuronide. Minor modulation of telomere length were observed. CONCLUSIONS: It is plausible that supplementing the high fat diet of CR mice with Cur + Pip may increase loss of body fat and suppresses HFD induced inflammation. Combination of Cur and Pip has potential to enhance CR effects for the prevention of metabolic syndrome. |
format | Online Article Text |
id | pubmed-5801844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-58018442018-02-14 Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β Miyazawa, Taiki Nakagawa, Kiyotaka Kim, Sharon H. Thomas, Michael J. Paul, Ligi Zingg, Jean-Marc Dolnikowski, Gregory G. Roberts, Susan B. Kimura, Fumiko Miyazawa, Teruo Azzi, Angelo Meydani, Mohsen Nutr Metab (Lond) Research BACKGROUND: Dietary bioactive compounds capable of improving metabolic profiles would be of great value, especially for overweight individuals undergoing a caloric restriction (CR) regimen. Curcumin (Cur), a possible anti-obesity compound, and piperine (Pip), a plausible enhancer of Cur’s bioavailability and efficacy, may be candidate agents for controlling body fat, metabolism and low grade inflammation. METHODS: 47 eight-week-old male C57BL/6 mice were fed a high fat diet (HFD) for 23 weeks to induce obesity. Then, mice were divided into 5 groups. Group 1 continued on HFD ad libitum. The other 4 groups underwent CR (reduced 10% HFD intake for 10 weeks, 20% for 20 weeks) with Cur, Pip, Cur + Pip or none of these. Percent body fat, plasma inflammatory markers associated with obesity (interferon (IFN)-γ, interleukin (IL)-10, IL-12 p70, IL-1β, IL-6 and KC/GRO), plasma Cur metabolites and liver telomere length were measured. RESULTS: Compared to the other groups, obese mice who underwent CR and received Cur + Pip in their diet lost more fat and had significantly lower IL-1β and KC/GRO. Tandem mass spectrometry analysis of plasma from obese mice under CR showed no difference in Cur metabolite levels between groups supplemented with Cur alone or combined with Pip. However, plasma IL-1β levels were inversely correlated with curcumin glucuronide. Minor modulation of telomere length were observed. CONCLUSIONS: It is plausible that supplementing the high fat diet of CR mice with Cur + Pip may increase loss of body fat and suppresses HFD induced inflammation. Combination of Cur and Pip has potential to enhance CR effects for the prevention of metabolic syndrome. BioMed Central 2018-02-06 /pmc/articles/PMC5801844/ /pubmed/29445415 http://dx.doi.org/10.1186/s12986-018-0250-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Miyazawa, Taiki Nakagawa, Kiyotaka Kim, Sharon H. Thomas, Michael J. Paul, Ligi Zingg, Jean-Marc Dolnikowski, Gregory G. Roberts, Susan B. Kimura, Fumiko Miyazawa, Teruo Azzi, Angelo Meydani, Mohsen Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β |
title | Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β |
title_full | Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β |
title_fullStr | Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β |
title_full_unstemmed | Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β |
title_short | Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β |
title_sort | curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801844/ https://www.ncbi.nlm.nih.gov/pubmed/29445415 http://dx.doi.org/10.1186/s12986-018-0250-6 |
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