MicroRNA-365 alleviates morphine analgesic tolerance via the inactivation of the ERK/CREB signaling pathway by negatively targeting β-arrestin2

BACKGROUND: Morphine is widely used in clinical practice for a class of analgesic drugs, long-term use of morphine will cause the action of tolerance. MicroRNAs have been reported to be involved in morphine analgesic tolerance.. METHODS: Forty male SD rats were selected and randomly divided into 5 g...

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Detalles Bibliográficos
Autores principales: Wu, Xian-Ping, She, Rui-Xuan, Yang, Yan-Ping, Xing, Zu-Min, Chen, Han-Wen, Zhang, Yi-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802062/
https://www.ncbi.nlm.nih.gov/pubmed/29415719
http://dx.doi.org/10.1186/s12929-018-0405-9

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