Promoter methylation of DNA damage repair (DDR) genes in human tumor entities: RBBP8/CtIP is almost exclusively methylated in bladder cancer

BACKGROUND: Genome-wide studies identified pan-cancer genes and shared biological networks affected by epigenetic dysregulation among diverse tumor entities. Here, we systematically screened for hypermethylation of DNA damage repair (DDR) genes in a comprehensive candidate-approach and exemplarily i...

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Detalles Bibliográficos
Autores principales: Mijnes, Jolein, Veeck, Jürgen, Gaisa, Nadine T., Burghardt, Eduard, de Ruijter, Tim C., Gostek, Sonja, Dahl, Edgar, Pfister, David, Schmid, Sebastian C., Knüchel, Ruth, Rose, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802064/
https://www.ncbi.nlm.nih.gov/pubmed/29445424
http://dx.doi.org/10.1186/s13148-018-0447-6

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