Cargando…
Vanillin improves scopolamine-induced memory impairment through restoration of ID1 expression in the mouse hippocampus
4-Hydroxy-3-methoxybenzaldehyde (vanillin), contained in a number of species of plant, has been reported to display beneficial effects against brain injuries. In the present study, the impact of vanillin on scopolamine-induced alterations in cognition and the expression of DNA binding protein inhibi...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802214/ https://www.ncbi.nlm.nih.gov/pubmed/29328430 http://dx.doi.org/10.3892/mmr.2018.8401 |
_version_ | 1783298502417186816 |
---|---|
author | Lee, Jae-Chul Kim, In Hye Cho, Jeong Hwi Lee, Tae-Kyeong Park, Joon Ha Ahn, Ji Hyeon Shin, Bich Na Yan, Bing Chun Kim, Jong-Dai Jeon, Yong Hwan Lee, Young Joo Won, Moo-Ho Kang, Il Jun |
author_facet | Lee, Jae-Chul Kim, In Hye Cho, Jeong Hwi Lee, Tae-Kyeong Park, Joon Ha Ahn, Ji Hyeon Shin, Bich Na Yan, Bing Chun Kim, Jong-Dai Jeon, Yong Hwan Lee, Young Joo Won, Moo-Ho Kang, Il Jun |
author_sort | Lee, Jae-Chul |
collection | PubMed |
description | 4-Hydroxy-3-methoxybenzaldehyde (vanillin), contained in a number of species of plant, has been reported to display beneficial effects against brain injuries. In the present study, the impact of vanillin on scopolamine-induced alterations in cognition and the expression of DNA binding protein inhibitor ID-1 (ID1), one of the inhibitors of DNA binding/differentiation proteins that regulate gene transcription, in the mouse hippocampus. Mice were treated with 1 mg/kg scopolamine with or without 40 mg/kg vanillin once daily for 4 weeks. Scopolamine-induced cognitive impairment was observed from 1 week and was deemed to be severe 4 weeks following the administration of scopolamine. However, treatment with vanillin in scopolamine-treated mice markedly attenuated cognitive impairment 4 weeks following treatment with scopolamine. ID1-immunoreactive cells were revealed in the hippocampus of vehicle-treated mice, and were hardly detected 4 weeks following treatment with scopolamine. However, treatment with vanillin in scopolamine-treated mice markedly restored ID1-immunoreactive cells and expression 4 weeks subsequent to treatment. The results of the present study suggested that vanillin may be beneficial for cognitive impairment, by preventing the reduction of ID1 expression which may be associated with cognitive impairment. |
format | Online Article Text |
id | pubmed-5802214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-58022142018-02-26 Vanillin improves scopolamine-induced memory impairment through restoration of ID1 expression in the mouse hippocampus Lee, Jae-Chul Kim, In Hye Cho, Jeong Hwi Lee, Tae-Kyeong Park, Joon Ha Ahn, Ji Hyeon Shin, Bich Na Yan, Bing Chun Kim, Jong-Dai Jeon, Yong Hwan Lee, Young Joo Won, Moo-Ho Kang, Il Jun Mol Med Rep Articles 4-Hydroxy-3-methoxybenzaldehyde (vanillin), contained in a number of species of plant, has been reported to display beneficial effects against brain injuries. In the present study, the impact of vanillin on scopolamine-induced alterations in cognition and the expression of DNA binding protein inhibitor ID-1 (ID1), one of the inhibitors of DNA binding/differentiation proteins that regulate gene transcription, in the mouse hippocampus. Mice were treated with 1 mg/kg scopolamine with or without 40 mg/kg vanillin once daily for 4 weeks. Scopolamine-induced cognitive impairment was observed from 1 week and was deemed to be severe 4 weeks following the administration of scopolamine. However, treatment with vanillin in scopolamine-treated mice markedly attenuated cognitive impairment 4 weeks following treatment with scopolamine. ID1-immunoreactive cells were revealed in the hippocampus of vehicle-treated mice, and were hardly detected 4 weeks following treatment with scopolamine. However, treatment with vanillin in scopolamine-treated mice markedly restored ID1-immunoreactive cells and expression 4 weeks subsequent to treatment. The results of the present study suggested that vanillin may be beneficial for cognitive impairment, by preventing the reduction of ID1 expression which may be associated with cognitive impairment. D.A. Spandidos 2018-03 2018-01-09 /pmc/articles/PMC5802214/ /pubmed/29328430 http://dx.doi.org/10.3892/mmr.2018.8401 Text en Copyright: © Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Lee, Jae-Chul Kim, In Hye Cho, Jeong Hwi Lee, Tae-Kyeong Park, Joon Ha Ahn, Ji Hyeon Shin, Bich Na Yan, Bing Chun Kim, Jong-Dai Jeon, Yong Hwan Lee, Young Joo Won, Moo-Ho Kang, Il Jun Vanillin improves scopolamine-induced memory impairment through restoration of ID1 expression in the mouse hippocampus |
title | Vanillin improves scopolamine-induced memory impairment through restoration of ID1 expression in the mouse hippocampus |
title_full | Vanillin improves scopolamine-induced memory impairment through restoration of ID1 expression in the mouse hippocampus |
title_fullStr | Vanillin improves scopolamine-induced memory impairment through restoration of ID1 expression in the mouse hippocampus |
title_full_unstemmed | Vanillin improves scopolamine-induced memory impairment through restoration of ID1 expression in the mouse hippocampus |
title_short | Vanillin improves scopolamine-induced memory impairment through restoration of ID1 expression in the mouse hippocampus |
title_sort | vanillin improves scopolamine-induced memory impairment through restoration of id1 expression in the mouse hippocampus |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802214/ https://www.ncbi.nlm.nih.gov/pubmed/29328430 http://dx.doi.org/10.3892/mmr.2018.8401 |
work_keys_str_mv | AT leejaechul vanillinimprovesscopolamineinducedmemoryimpairmentthroughrestorationofid1expressioninthemousehippocampus AT kiminhye vanillinimprovesscopolamineinducedmemoryimpairmentthroughrestorationofid1expressioninthemousehippocampus AT chojeonghwi vanillinimprovesscopolamineinducedmemoryimpairmentthroughrestorationofid1expressioninthemousehippocampus AT leetaekyeong vanillinimprovesscopolamineinducedmemoryimpairmentthroughrestorationofid1expressioninthemousehippocampus AT parkjoonha vanillinimprovesscopolamineinducedmemoryimpairmentthroughrestorationofid1expressioninthemousehippocampus AT ahnjihyeon vanillinimprovesscopolamineinducedmemoryimpairmentthroughrestorationofid1expressioninthemousehippocampus AT shinbichna vanillinimprovesscopolamineinducedmemoryimpairmentthroughrestorationofid1expressioninthemousehippocampus AT yanbingchun vanillinimprovesscopolamineinducedmemoryimpairmentthroughrestorationofid1expressioninthemousehippocampus AT kimjongdai vanillinimprovesscopolamineinducedmemoryimpairmentthroughrestorationofid1expressioninthemousehippocampus AT jeonyonghwan vanillinimprovesscopolamineinducedmemoryimpairmentthroughrestorationofid1expressioninthemousehippocampus AT leeyoungjoo vanillinimprovesscopolamineinducedmemoryimpairmentthroughrestorationofid1expressioninthemousehippocampus AT wonmooho vanillinimprovesscopolamineinducedmemoryimpairmentthroughrestorationofid1expressioninthemousehippocampus AT kangiljun vanillinimprovesscopolamineinducedmemoryimpairmentthroughrestorationofid1expressioninthemousehippocampus |