Cargando…
PGC-1α ameliorates kidney fibrosis in mice with diabetic kidney disease through an antioxidative mechanism
The production of reactive oxygen species (ROS) is a common phenomenon in podocyte impairment, which leads to the irreversible progression of chronic kidney diseases, such as diabetic kidney disease (DKD). Previous research has indicated that peroxisome proliferator-activated receptor γ (PPARγ) coac...
Autores principales: | Zhang, Liwen, Liu, Jian, Zhou, Fangfang, Wang, Weiming, Chen, Nan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802225/ https://www.ncbi.nlm.nih.gov/pubmed/29344670 http://dx.doi.org/10.3892/mmr.2018.8433 |
Ejemplares similares
-
C/EBPα deficiency in podocytes aggravates podocyte senescence and kidney injury in aging mice
por: Zhang, Liwen, et al.
Publicado: (2019) -
The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases
por: Fontecha-Barriuso, Miguel, et al.
Publicado: (2020) -
PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis
por: Nam, Bo Young, et al.
Publicado: (2022) -
Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1α pathway
por: Li, Xuechen, et al.
Publicado: (2022) -
Activation of AMPK-PGC-1α pathway ameliorates peritoneal dialysis related peritoneal fibrosis in mice by enhancing mitochondrial biogenesis
por: Wu, Jun, et al.
Publicado: (2022)