Cargando…

Childhood leukaemia near nuclear sites in Belgium, 2002–2008

This paper describes an ecological study investigating whether there is an excess incidence of acute leukaemia among children aged 0–14 years living in the vicinity of the nuclear sites in Belgium. Poisson regression modelling was carried out for proximity areas of varying sizes. In addition, the hy...

Descripción completa

Detalles Bibliográficos
Autores principales: Bollaerts, Kaatje, Simons, Koen, Van Bladel, Lodewijk, De Smedt, Tom, Sonck, Michel, Fierens, Sébastien, Poffijn, André, Geraets, David, Gosselin, Pol, Van Oyen, Herman, Francart, Julie, Van Nieuwenhuyse, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802263/
https://www.ncbi.nlm.nih.gov/pubmed/27380513
http://dx.doi.org/10.1097/CEJ.0000000000000272
_version_ 1783298509397557248
author Bollaerts, Kaatje
Simons, Koen
Van Bladel, Lodewijk
De Smedt, Tom
Sonck, Michel
Fierens, Sébastien
Poffijn, André
Geraets, David
Gosselin, Pol
Van Oyen, Herman
Francart, Julie
Van Nieuwenhuyse, An
author_facet Bollaerts, Kaatje
Simons, Koen
Van Bladel, Lodewijk
De Smedt, Tom
Sonck, Michel
Fierens, Sébastien
Poffijn, André
Geraets, David
Gosselin, Pol
Van Oyen, Herman
Francart, Julie
Van Nieuwenhuyse, An
author_sort Bollaerts, Kaatje
collection PubMed
description This paper describes an ecological study investigating whether there is an excess incidence of acute leukaemia among children aged 0–14 years living in the vicinity of the nuclear sites in Belgium. Poisson regression modelling was carried out for proximity areas of varying sizes. In addition, the hypothesis of a gradient in leukaemia incidence with increasing levels of surrogate exposures was explored by means of focused hypothesis tests and generalized additive models. For the surrogate exposures, three proxies were used, that is, residential proximity to the nuclear site, prevailing winds and simulated radioactive discharges, on the basis of mathematical dispersion modelling. No excess incidence of acute leukaemia was observed around the nuclear power plants of Doel or Tihange nor around the nuclear site of Fleurus, which is a major manufacturer of radioactive isotopes in Europe. Around the site of Mol-Dessel, however, two- to three-fold increased leukaemia incidence rates were found in children aged 0–14 years living in the 0–5, 0–10 and the 0–15 km proximity areas. For this site, there was evidence for a gradient in leukaemia incidence with increased proximity, prevailing winds and simulated radioactive discharges, suggesting a potential link with the site that needs further investigation. An increased incidence of acute leukaemia in children aged 0–14 years was observed around one nuclear site that hosted reprocessing activities in the past and where nuclear research activities and radioactive waste treatment are ongoing.
format Online
Article
Text
id pubmed-5802263
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-58022632018-02-13 Childhood leukaemia near nuclear sites in Belgium, 2002–2008 Bollaerts, Kaatje Simons, Koen Van Bladel, Lodewijk De Smedt, Tom Sonck, Michel Fierens, Sébastien Poffijn, André Geraets, David Gosselin, Pol Van Oyen, Herman Francart, Julie Van Nieuwenhuyse, An Eur J Cancer Prev Research Papers: Life Style This paper describes an ecological study investigating whether there is an excess incidence of acute leukaemia among children aged 0–14 years living in the vicinity of the nuclear sites in Belgium. Poisson regression modelling was carried out for proximity areas of varying sizes. In addition, the hypothesis of a gradient in leukaemia incidence with increasing levels of surrogate exposures was explored by means of focused hypothesis tests and generalized additive models. For the surrogate exposures, three proxies were used, that is, residential proximity to the nuclear site, prevailing winds and simulated radioactive discharges, on the basis of mathematical dispersion modelling. No excess incidence of acute leukaemia was observed around the nuclear power plants of Doel or Tihange nor around the nuclear site of Fleurus, which is a major manufacturer of radioactive isotopes in Europe. Around the site of Mol-Dessel, however, two- to three-fold increased leukaemia incidence rates were found in children aged 0–14 years living in the 0–5, 0–10 and the 0–15 km proximity areas. For this site, there was evidence for a gradient in leukaemia incidence with increased proximity, prevailing winds and simulated radioactive discharges, suggesting a potential link with the site that needs further investigation. An increased incidence of acute leukaemia in children aged 0–14 years was observed around one nuclear site that hosted reprocessing activities in the past and where nuclear research activities and radioactive waste treatment are ongoing. Lippincott Williams & Wilkins 2018-03 2016-07-15 /pmc/articles/PMC5802263/ /pubmed/27380513 http://dx.doi.org/10.1097/CEJ.0000000000000272 Text en Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Research Papers: Life Style
Bollaerts, Kaatje
Simons, Koen
Van Bladel, Lodewijk
De Smedt, Tom
Sonck, Michel
Fierens, Sébastien
Poffijn, André
Geraets, David
Gosselin, Pol
Van Oyen, Herman
Francart, Julie
Van Nieuwenhuyse, An
Childhood leukaemia near nuclear sites in Belgium, 2002–2008
title Childhood leukaemia near nuclear sites in Belgium, 2002–2008
title_full Childhood leukaemia near nuclear sites in Belgium, 2002–2008
title_fullStr Childhood leukaemia near nuclear sites in Belgium, 2002–2008
title_full_unstemmed Childhood leukaemia near nuclear sites in Belgium, 2002–2008
title_short Childhood leukaemia near nuclear sites in Belgium, 2002–2008
title_sort childhood leukaemia near nuclear sites in belgium, 2002–2008
topic Research Papers: Life Style
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802263/
https://www.ncbi.nlm.nih.gov/pubmed/27380513
http://dx.doi.org/10.1097/CEJ.0000000000000272
work_keys_str_mv AT bollaertskaatje childhoodleukaemianearnuclearsitesinbelgium20022008
AT simonskoen childhoodleukaemianearnuclearsitesinbelgium20022008
AT vanbladellodewijk childhoodleukaemianearnuclearsitesinbelgium20022008
AT desmedttom childhoodleukaemianearnuclearsitesinbelgium20022008
AT sonckmichel childhoodleukaemianearnuclearsitesinbelgium20022008
AT fierenssebastien childhoodleukaemianearnuclearsitesinbelgium20022008
AT poffijnandre childhoodleukaemianearnuclearsitesinbelgium20022008
AT geraetsdavid childhoodleukaemianearnuclearsitesinbelgium20022008
AT gosselinpol childhoodleukaemianearnuclearsitesinbelgium20022008
AT vanoyenherman childhoodleukaemianearnuclearsitesinbelgium20022008
AT francartjulie childhoodleukaemianearnuclearsitesinbelgium20022008
AT vannieuwenhuysean childhoodleukaemianearnuclearsitesinbelgium20022008