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Childhood leukaemia near nuclear sites in Belgium, 2002–2008
This paper describes an ecological study investigating whether there is an excess incidence of acute leukaemia among children aged 0–14 years living in the vicinity of the nuclear sites in Belgium. Poisson regression modelling was carried out for proximity areas of varying sizes. In addition, the hy...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802263/ https://www.ncbi.nlm.nih.gov/pubmed/27380513 http://dx.doi.org/10.1097/CEJ.0000000000000272 |
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author | Bollaerts, Kaatje Simons, Koen Van Bladel, Lodewijk De Smedt, Tom Sonck, Michel Fierens, Sébastien Poffijn, André Geraets, David Gosselin, Pol Van Oyen, Herman Francart, Julie Van Nieuwenhuyse, An |
author_facet | Bollaerts, Kaatje Simons, Koen Van Bladel, Lodewijk De Smedt, Tom Sonck, Michel Fierens, Sébastien Poffijn, André Geraets, David Gosselin, Pol Van Oyen, Herman Francart, Julie Van Nieuwenhuyse, An |
author_sort | Bollaerts, Kaatje |
collection | PubMed |
description | This paper describes an ecological study investigating whether there is an excess incidence of acute leukaemia among children aged 0–14 years living in the vicinity of the nuclear sites in Belgium. Poisson regression modelling was carried out for proximity areas of varying sizes. In addition, the hypothesis of a gradient in leukaemia incidence with increasing levels of surrogate exposures was explored by means of focused hypothesis tests and generalized additive models. For the surrogate exposures, three proxies were used, that is, residential proximity to the nuclear site, prevailing winds and simulated radioactive discharges, on the basis of mathematical dispersion modelling. No excess incidence of acute leukaemia was observed around the nuclear power plants of Doel or Tihange nor around the nuclear site of Fleurus, which is a major manufacturer of radioactive isotopes in Europe. Around the site of Mol-Dessel, however, two- to three-fold increased leukaemia incidence rates were found in children aged 0–14 years living in the 0–5, 0–10 and the 0–15 km proximity areas. For this site, there was evidence for a gradient in leukaemia incidence with increased proximity, prevailing winds and simulated radioactive discharges, suggesting a potential link with the site that needs further investigation. An increased incidence of acute leukaemia in children aged 0–14 years was observed around one nuclear site that hosted reprocessing activities in the past and where nuclear research activities and radioactive waste treatment are ongoing. |
format | Online Article Text |
id | pubmed-5802263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-58022632018-02-13 Childhood leukaemia near nuclear sites in Belgium, 2002–2008 Bollaerts, Kaatje Simons, Koen Van Bladel, Lodewijk De Smedt, Tom Sonck, Michel Fierens, Sébastien Poffijn, André Geraets, David Gosselin, Pol Van Oyen, Herman Francart, Julie Van Nieuwenhuyse, An Eur J Cancer Prev Research Papers: Life Style This paper describes an ecological study investigating whether there is an excess incidence of acute leukaemia among children aged 0–14 years living in the vicinity of the nuclear sites in Belgium. Poisson regression modelling was carried out for proximity areas of varying sizes. In addition, the hypothesis of a gradient in leukaemia incidence with increasing levels of surrogate exposures was explored by means of focused hypothesis tests and generalized additive models. For the surrogate exposures, three proxies were used, that is, residential proximity to the nuclear site, prevailing winds and simulated radioactive discharges, on the basis of mathematical dispersion modelling. No excess incidence of acute leukaemia was observed around the nuclear power plants of Doel or Tihange nor around the nuclear site of Fleurus, which is a major manufacturer of radioactive isotopes in Europe. Around the site of Mol-Dessel, however, two- to three-fold increased leukaemia incidence rates were found in children aged 0–14 years living in the 0–5, 0–10 and the 0–15 km proximity areas. For this site, there was evidence for a gradient in leukaemia incidence with increased proximity, prevailing winds and simulated radioactive discharges, suggesting a potential link with the site that needs further investigation. An increased incidence of acute leukaemia in children aged 0–14 years was observed around one nuclear site that hosted reprocessing activities in the past and where nuclear research activities and radioactive waste treatment are ongoing. Lippincott Williams & Wilkins 2018-03 2016-07-15 /pmc/articles/PMC5802263/ /pubmed/27380513 http://dx.doi.org/10.1097/CEJ.0000000000000272 Text en Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Research Papers: Life Style Bollaerts, Kaatje Simons, Koen Van Bladel, Lodewijk De Smedt, Tom Sonck, Michel Fierens, Sébastien Poffijn, André Geraets, David Gosselin, Pol Van Oyen, Herman Francart, Julie Van Nieuwenhuyse, An Childhood leukaemia near nuclear sites in Belgium, 2002–2008 |
title | Childhood leukaemia near nuclear sites in Belgium, 2002–2008 |
title_full | Childhood leukaemia near nuclear sites in Belgium, 2002–2008 |
title_fullStr | Childhood leukaemia near nuclear sites in Belgium, 2002–2008 |
title_full_unstemmed | Childhood leukaemia near nuclear sites in Belgium, 2002–2008 |
title_short | Childhood leukaemia near nuclear sites in Belgium, 2002–2008 |
title_sort | childhood leukaemia near nuclear sites in belgium, 2002–2008 |
topic | Research Papers: Life Style |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802263/ https://www.ncbi.nlm.nih.gov/pubmed/27380513 http://dx.doi.org/10.1097/CEJ.0000000000000272 |
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