Cobalt catalyzed sp(3) C–H amination utilizing aryl azides

A dinuclear Co(ii) complex supported by a modular, tunable redox-active ligand system is capable of selective C–H amination to form indolines from aryl azides in good yields at low (1 mol%) catalyst loading. The reaction is tolerant of medicinally relevant heterocycles, such as pyridine and indole,...

Descripción completa

Detalles Bibliográficos
Autores principales: Villanueva, Omar, Weldy, Nina Mace, Blakey, Simon B., MacBeth, Cora E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802275/
https://www.ncbi.nlm.nih.gov/pubmed/29435216
http://dx.doi.org/10.1039/c5sc01162k
_version_ 1783298511797747712
author Villanueva, Omar
Weldy, Nina Mace
Blakey, Simon B.
MacBeth, Cora E.
author_facet Villanueva, Omar
Weldy, Nina Mace
Blakey, Simon B.
MacBeth, Cora E.
author_sort Villanueva, Omar
collection PubMed
description A dinuclear Co(ii) complex supported by a modular, tunable redox-active ligand system is capable of selective C–H amination to form indolines from aryl azides in good yields at low (1 mol%) catalyst loading. The reaction is tolerant of medicinally relevant heterocycles, such as pyridine and indole, and can be used to form 5-, 6-, and 7-membered rings. The synthetic versatility obtained using low loadings of an earth abundant transition metal complex represents a significant advance in catalytic C–H amination technology.
format Online
Article
Text
id pubmed-5802275
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-58022752018-02-12 Cobalt catalyzed sp(3) C–H amination utilizing aryl azides Villanueva, Omar Weldy, Nina Mace Blakey, Simon B. MacBeth, Cora E. Chem Sci Chemistry A dinuclear Co(ii) complex supported by a modular, tunable redox-active ligand system is capable of selective C–H amination to form indolines from aryl azides in good yields at low (1 mol%) catalyst loading. The reaction is tolerant of medicinally relevant heterocycles, such as pyridine and indole, and can be used to form 5-, 6-, and 7-membered rings. The synthetic versatility obtained using low loadings of an earth abundant transition metal complex represents a significant advance in catalytic C–H amination technology. Royal Society of Chemistry 2015-11-01 2015-07-30 /pmc/articles/PMC5802275/ /pubmed/29435216 http://dx.doi.org/10.1039/c5sc01162k Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Villanueva, Omar
Weldy, Nina Mace
Blakey, Simon B.
MacBeth, Cora E.
Cobalt catalyzed sp(3) C–H amination utilizing aryl azides
title Cobalt catalyzed sp(3) C–H amination utilizing aryl azides
title_full Cobalt catalyzed sp(3) C–H amination utilizing aryl azides
title_fullStr Cobalt catalyzed sp(3) C–H amination utilizing aryl azides
title_full_unstemmed Cobalt catalyzed sp(3) C–H amination utilizing aryl azides
title_short Cobalt catalyzed sp(3) C–H amination utilizing aryl azides
title_sort cobalt catalyzed sp(3) c–h amination utilizing aryl azides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802275/
https://www.ncbi.nlm.nih.gov/pubmed/29435216
http://dx.doi.org/10.1039/c5sc01162k
work_keys_str_mv AT villanuevaomar cobaltcatalyzedsp3chaminationutilizingarylazides
AT weldyninamace cobaltcatalyzedsp3chaminationutilizingarylazides
AT blakeysimonb cobaltcatalyzedsp3chaminationutilizingarylazides
AT macbethcorae cobaltcatalyzedsp3chaminationutilizingarylazides

Ejemplares similares