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t-SNARE Transmembrane Domain Clustering Modulates Lipid Organization and Membrane Curvature

[Image: see text] The t-SNARE complex plays a central role in neuronal fusion. Its components, syntaxin-1 and SNAP25, are largely present in individual clusters and partially colocalize at the presumptive fusion site. How these protein clusters modify local lipid composition and membrane morphology...

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Detalles Bibliográficos
Autores principales: Sharma, Satyan, Lindau, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802331/
https://www.ncbi.nlm.nih.gov/pubmed/29231734
http://dx.doi.org/10.1021/jacs.7b10677