Cargando…

Synthesis and Biological Evaluations of Ring Substituted Tetrahydroisoquinolines (THIQs) as Anti-Breast Cancer Agents

Breast cancer is a leading cause of mortality among women, resulting in more than half a million deaths worldwide every year. Although chemotherapeutic drugs remain the main stay of cancer treatment, it is observed that toxicity to normal cells poses a limitation to their therapeutic values. Moreove...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eyunni, Suresh VK, Gangapuram, Madhavi, Mochona, Bereket, Mateeva, Nelly, Redda, Kinfe K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802351/ https://www.ncbi.nlm.nih.gov/pubmed/29430288 http://dx.doi.org/10.4172/1948-5956.1000470

Ejemplares similares

Design, Synthesis and Evaluation of Novel N-Substituted-[Benzoylamino]-5-Ethyl-1,2,3,6-Tetrahydropyridines as Potential Anti-Cancer Agents
por: Henderson, Elizabeth D, et al.
Publicado: (2019)

Transcriptome Profile Analysis of Triple-Negative Breast Cancer Cells in Response to a Novel Cytostatic Tetrahydroisoquinoline Compared to Paclitaxel
por: Gangapuram, Madhavi, et al.
Publicado: (2021)

The Antiproliferative Effects of Flavonoid MAO Inhibitors on Prostate Cancer Cells
por: Zarmouh, Najla O., et al.
Publicado: (2020)

Thymoquinone Inhibition of Chemokines in TNF-α-Induced Inflammatory and Metastatic Effects in Triple-Negative Breast Cancer Cells
por: Adinew, Getinet M., et al.
Publicado: (2023)

Synthesis of C3/C1-Substituted Tetrahydroisoquinolines
por: Mihoubi, Mohamed, et al.
Publicado: (2015)

Substrate controlled, regioselective carbopalladation for the one-pot synthesis of C4-substituted tetrahydroisoquinoline analogues
por: Krishna Reddy, Singarajanahalli Mundarinti, et al.
Publicado: (2020)

Synthesis and Contractile Activity of Substituted 1,2,3,4-Tetrahydroisoquinolines
por: Ivanov, Iliyan, et al.
Publicado: (2011)

Silica-Supported Polyphosphoric Acid in the Synthesis of 4-Substituted Tetrahydroisoquinoline Derivatives
por: Manolov, Stanimir, et al.
Publicado: (2013)

Facile Synthesis of 3-Substituted Thiazolo[2,3-α]tetrahydroisoquinolines
por: Huang, Sheng-Han, et al.
Publicado: (2021)

Direct and Efficient C(sp(3))–H Functionalization of N-Acyl/Sulfonyl Tetrahydroisoquinolines (THIQs) With Electron-Rich Nucleophiles via 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone (DDQ) Oxidation
por: Yu, Heesun, et al.
Publicado: (2020)

Lipase-Catalyzed Strategies for the Preparation of Enantiomeric THIQ and THβC Derivatives: Green Aspects
por: Orsy, György, et al.
Publicado: (2023)

1,2,3,4,6-Penta-O-galloylglucose within Galla Chinensis Inhibits Human LDH-A and Attenuates Cell Proliferation in MDA-MB-231 Breast Cancer Cells
por: Deiab, Shihab, et al.
Publicado: (2015)

Structure–Activity Relationships of 7-Substituted Dimethyltyrosine-Tetrahydroisoquinoline Opioid Peptidomimetics
por: Montgomery, Deanna, et al.
Publicado: (2019)

The Discovery of Imine Reductases and their Utilisation for the Synthesis of Tetrahydroisoquinolines
por: Cárdenas‐Fernández, Max, et al.
Publicado: (2023)

A Small Molecule Agonist THIQ as a Novel Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants
por: Huang, Hui, et al.
Publicado: (2014)

One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues
por: Zhao, Jianxiong, et al.
Publicado: (2018)

Design and Synthesis of New Acyl Urea Analogs as Potential σ1R Ligands
por: Thapa, Rajesh, et al.
Publicado: (2023)

Synthesis of 1-(para-methoxyphenyl)tetrazolyl-Substituted 1,2,3,4-Tetrahydroisoquinolines and Their Transformations Involving Activated Alkynes
por: Titov, Alexander A., et al.
Publicado: (2018)

A Class of Promising Acaricidal Tetrahydroisoquinoline Derivatives: Synthesis, Biological Evaluation and Structure-Activity Relationships
por: Yang, Rui, et al.
Publicado: (2014)

A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids
por: Pyne, Michael E., et al.
Publicado: (2020)

Recent Advances in the Total Synthesis of the Tetrahydroisoquinoline Alkaloids (2002–2020)
por: Kim, Alexia N., et al.
Publicado: (2023)

One-pot functionalisation of N-substituted tetrahydroisoquinolines by photooxidation and tunable organometallic trapping of iminium intermediates
por: Barham, Joshua P, et al.
Publicado: (2014)

Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis
por: Lu, Guo-Liang, et al.
Publicado: (2020)

Neurotoxic Effects of Tetrahydroisoquinolines and Underlying Mechanisms
por: Surh, Young-Joon, et al.
Publicado: (2010)

Enzymatic and Chemoenzymatic Three‐Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines
por: Erdmann, Vanessa, et al.
Publicado: (2017)

Enantioselective synthesis of isochromans and tetrahydroisoquinolines by C–H insertion of donor/donor carbenes
por: Nickerson, Leslie A., et al.
Publicado: (2019)

Synthesis, Structural and Biological Properties of the Ring-A Sulfonamido Substituted Chalcones: A Review
por: Mphahlele, Malose J.
Publicado: (2021)

Introduction of chirality at C1 position of 1-substituted-3,4-dihydroisoquinoline by its enantioselective reduction: synthesis of chiral 1-substituted-1,2,3,4-tetrahydroisoquinoline – a review
por: Asif, Md. Moaz Ahmed, et al.
Publicado: (2023)

Concise synthesis of α-cyano tetrahydroisoquinolines with a quaternary center via Strecker reaction
por: Ji, Yue, et al.
Publicado: (2021)

Correction: Enantioselective synthesis of isochromans and tetrahydroisoquinolines by C–H insertion of donor/donor carbenes
por: Nickerson, Leslie A., et al.
Publicado: (2020)

Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors
por: Leese, Mathew P., et al.
Publicado: (2011)

Synthesis of new substituted 7,12-dihydro-6,12-methanodibenzo[c,f]azocine-5-carboxylic acids containing a tetracyclic tetrahydroisoquinoline core structure
por: Grajewska, Agnieszka, et al.
Publicado: (2021)

Synthesis of 8-Fluoro-3,4-dihydroisoquinoline and Its Transformation to 1,8-Disubstituted Tetrahydroisoquinolines
por: Hargitai, Csilla, et al.
Publicado: (2018)

Iron Trichloride-Mediated Cascade Reaction of Aminosugar Derivatives for the Synthesis of Fused Tetrahydroisoquinoline–Tetrahydrofuran Systems
por: Rodríguez-Álvarez, Sandra, et al.
Publicado: (2022)

Nano-rings with a handle – Synthesis of substituted cycloparaphenylenes
por: Tran-Van, Anne-Florence, et al.
Publicado: (2014)

Multi-enzyme catalysed processes using purified and whole-cell biocatalysts towards a 1,3,4-substituted tetrahydroisoquinoline
por: Weber, Douglas, et al.
Publicado: (2023)

Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer
por: Chen, Danqi, et al.
Publicado: (2016)

Improved simplicity and practicability in copper-catalyzed alkynylation of tetrahydroisoquinoline
por: Gröll, Birgit, et al.
Publicado: (2016)

Design and Synthesis of Novel Pyrazole-Substituted Different Nitrogenous Heterocyclic Ring Systems as Potential Anti-Inflammatory Agents
por: Nossier, Eman S., et al.
Publicado: (2017)

Design, Synthesis and Biological Evaluation of Novel 4-Substituted Coumarin Derivatives as Antitumor Agents
por: An, Ran, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lvlai7uoet9823hhua3apsckl0