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Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit

Involuntary movements as seen in repetitive disorders such as Tourette Syndrome (TS) results from cortical hyperexcitability that arise due to striato-thalamo-cortical circuit (STC) imbalance. Transcranial direct current stimulation (tDCS) is a stimulation procedure that changes cortical excitabilit...

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Autores principales: Edemann-Callesen, Henriette, Habelt, Bettina, Wieske, Franziska, Jackson, Mark, Khadka, Niranjan, Mattei, Daniele, Bernhardt, Nadine, Heinz, Andreas, Liebetanz, David, Bikson, Marom, Padberg, Frank, Hadar, Ravit, Nitsche, Michael A., Winter, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802458/
https://www.ncbi.nlm.nih.gov/pubmed/29317605
http://dx.doi.org/10.1038/s41398-017-0059-5
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author Edemann-Callesen, Henriette
Habelt, Bettina
Wieske, Franziska
Jackson, Mark
Khadka, Niranjan
Mattei, Daniele
Bernhardt, Nadine
Heinz, Andreas
Liebetanz, David
Bikson, Marom
Padberg, Frank
Hadar, Ravit
Nitsche, Michael A.
Winter, Christine
author_facet Edemann-Callesen, Henriette
Habelt, Bettina
Wieske, Franziska
Jackson, Mark
Khadka, Niranjan
Mattei, Daniele
Bernhardt, Nadine
Heinz, Andreas
Liebetanz, David
Bikson, Marom
Padberg, Frank
Hadar, Ravit
Nitsche, Michael A.
Winter, Christine
author_sort Edemann-Callesen, Henriette
collection PubMed
description Involuntary movements as seen in repetitive disorders such as Tourette Syndrome (TS) results from cortical hyperexcitability that arise due to striato-thalamo-cortical circuit (STC) imbalance. Transcranial direct current stimulation (tDCS) is a stimulation procedure that changes cortical excitability, yet its relevance in repetitive disorders such as TS remains largely unexplored. Here, we employed the dopamine transporter-overexpressing (DAT-tg) rat model to investigate behavioral and neurobiological effects of frontal tDCS. The outcome of tDCS was pathology dependent, as anodal tDCS decreased repetitive behavior in the DAT-tg rats yet increased it in wild-type (wt) rats. Extensive deep brain stimulation (DBS) application and computational modeling assigned the response in DAT-tg rats to the sensorimotor pathway. Neurobiological assessment revealed cortical activity changes and increase in striatal inhibitory properties in the DAT-tg rats. Our findings show that tDCS reduces repetitive behavior in the DAT-tg rat through modulation of the sensorimotor STC circuit. This sets the stage for further investigating the usage of tDCS in repetitive disorders such as TS.
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spelling pubmed-58024582018-02-08 Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit Edemann-Callesen, Henriette Habelt, Bettina Wieske, Franziska Jackson, Mark Khadka, Niranjan Mattei, Daniele Bernhardt, Nadine Heinz, Andreas Liebetanz, David Bikson, Marom Padberg, Frank Hadar, Ravit Nitsche, Michael A. Winter, Christine Transl Psychiatry Article Involuntary movements as seen in repetitive disorders such as Tourette Syndrome (TS) results from cortical hyperexcitability that arise due to striato-thalamo-cortical circuit (STC) imbalance. Transcranial direct current stimulation (tDCS) is a stimulation procedure that changes cortical excitability, yet its relevance in repetitive disorders such as TS remains largely unexplored. Here, we employed the dopamine transporter-overexpressing (DAT-tg) rat model to investigate behavioral and neurobiological effects of frontal tDCS. The outcome of tDCS was pathology dependent, as anodal tDCS decreased repetitive behavior in the DAT-tg rats yet increased it in wild-type (wt) rats. Extensive deep brain stimulation (DBS) application and computational modeling assigned the response in DAT-tg rats to the sensorimotor pathway. Neurobiological assessment revealed cortical activity changes and increase in striatal inhibitory properties in the DAT-tg rats. Our findings show that tDCS reduces repetitive behavior in the DAT-tg rat through modulation of the sensorimotor STC circuit. This sets the stage for further investigating the usage of tDCS in repetitive disorders such as TS. Nature Publishing Group UK 2018-01-10 /pmc/articles/PMC5802458/ /pubmed/29317605 http://dx.doi.org/10.1038/s41398-017-0059-5 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Edemann-Callesen, Henriette
Habelt, Bettina
Wieske, Franziska
Jackson, Mark
Khadka, Niranjan
Mattei, Daniele
Bernhardt, Nadine
Heinz, Andreas
Liebetanz, David
Bikson, Marom
Padberg, Frank
Hadar, Ravit
Nitsche, Michael A.
Winter, Christine
Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit
title Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit
title_full Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit
title_fullStr Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit
title_full_unstemmed Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit
title_short Non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit
title_sort non-invasive modulation reduces repetitive behavior in a rat model through the sensorimotor cortico-striatal circuit
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802458/
https://www.ncbi.nlm.nih.gov/pubmed/29317605
http://dx.doi.org/10.1038/s41398-017-0059-5
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