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Social affective context reveals altered network dynamics in schizophrenia patients

Impairments in social cognition and interactions are core psychopathologies in schizophrenia, often manifesting as an inability to appropriately relate to the intentions and feelings of others. Neuroimaging has helped to demarcate the dynamics of two distinct functional connectivity circuits underly...

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Autores principales: Hendler, Talma, Raz, Gal, Shimrit, Solnik, Jacob, Yael, Lin, Tamar, Roseman, Leor, Wahid, Wahid Madah, Kremer, Ilana, Kupchik, Marina, Kotler, Moshe, Bleich-Cohen, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802465/
https://www.ncbi.nlm.nih.gov/pubmed/29382814
http://dx.doi.org/10.1038/s41398-017-0055-9
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author Hendler, Talma
Raz, Gal
Shimrit, Solnik
Jacob, Yael
Lin, Tamar
Roseman, Leor
Wahid, Wahid Madah
Kremer, Ilana
Kupchik, Marina
Kotler, Moshe
Bleich-Cohen, Maya
author_facet Hendler, Talma
Raz, Gal
Shimrit, Solnik
Jacob, Yael
Lin, Tamar
Roseman, Leor
Wahid, Wahid Madah
Kremer, Ilana
Kupchik, Marina
Kotler, Moshe
Bleich-Cohen, Maya
author_sort Hendler, Talma
collection PubMed
description Impairments in social cognition and interactions are core psychopathologies in schizophrenia, often manifesting as an inability to appropriately relate to the intentions and feelings of others. Neuroimaging has helped to demarcate the dynamics of two distinct functional connectivity circuits underlying the social-affective processes related to mentalization (known as Theory of Mind, ToM) and somatic-affiliation (known as Embodied Simulation, ES). While evidence points to abnormal activation patterns within these networks among those suffering from schizophrenia, it is yet unclear however, if these patients exhibit this abnormal functional connectivity in the context of social-affective experiences. The current fMRI study, investigated functional connectivity dynamics within ToM and ES networks as subjects experienced evolving cinematic portrayals of fear. During scanning, schizophrenia patients and healthy controls passively watched a cinematic scene in which a mother and her son face various threatening events. Participants then provided a continuous and retrospective report of their fear intensity during a second viewing outside the scanner. Using network cohesion index (NCI) analysis, we examined modulations of ES-related and ToM-related functional connectivity dynamics and their relation to symptom severity and the continuous emotional ratings of the induced cinematic fear. Compared to patients, healthy controls showed higher ES-NCI and marginally lower ToM-NCI during emotional peaks. Cross-correlation analysis revealed an intriguing dynamic between NCI and the inter-group difference of reported fear. Schizophrenia patients rated their fear as lower relative to healthy controls, shortly after exhibiting lower ES connectivity. This increased difference in rating was also followed by higher ToM connectivity among schizophrenia patients. The clinical relevance of these findings is further highlighted by the following two results: (a) ToM-NCI was found to have a strong correlation with the severity of general symptoms during one of the two main emotional peaks (Spearman R = 0.77); and (b) k-mean clustering demonstrated that the networks’ NCI dynamic during the social-affective context reliably differentiated between patients and controls. Together, these findings point to a possible neural marker for abnormal social-affective processing in schizophrenia, manifested as the disturbed balance between two functional networks involved in social-affective affiliation. This in turn suggests that exaggerated mentalization over somatic-affiliative processing, in response to another’s’ distress may underlie social-affective deficits in schizophrenia.
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spelling pubmed-58024652018-02-08 Social affective context reveals altered network dynamics in schizophrenia patients Hendler, Talma Raz, Gal Shimrit, Solnik Jacob, Yael Lin, Tamar Roseman, Leor Wahid, Wahid Madah Kremer, Ilana Kupchik, Marina Kotler, Moshe Bleich-Cohen, Maya Transl Psychiatry Article Impairments in social cognition and interactions are core psychopathologies in schizophrenia, often manifesting as an inability to appropriately relate to the intentions and feelings of others. Neuroimaging has helped to demarcate the dynamics of two distinct functional connectivity circuits underlying the social-affective processes related to mentalization (known as Theory of Mind, ToM) and somatic-affiliation (known as Embodied Simulation, ES). While evidence points to abnormal activation patterns within these networks among those suffering from schizophrenia, it is yet unclear however, if these patients exhibit this abnormal functional connectivity in the context of social-affective experiences. The current fMRI study, investigated functional connectivity dynamics within ToM and ES networks as subjects experienced evolving cinematic portrayals of fear. During scanning, schizophrenia patients and healthy controls passively watched a cinematic scene in which a mother and her son face various threatening events. Participants then provided a continuous and retrospective report of their fear intensity during a second viewing outside the scanner. Using network cohesion index (NCI) analysis, we examined modulations of ES-related and ToM-related functional connectivity dynamics and their relation to symptom severity and the continuous emotional ratings of the induced cinematic fear. Compared to patients, healthy controls showed higher ES-NCI and marginally lower ToM-NCI during emotional peaks. Cross-correlation analysis revealed an intriguing dynamic between NCI and the inter-group difference of reported fear. Schizophrenia patients rated their fear as lower relative to healthy controls, shortly after exhibiting lower ES connectivity. This increased difference in rating was also followed by higher ToM connectivity among schizophrenia patients. The clinical relevance of these findings is further highlighted by the following two results: (a) ToM-NCI was found to have a strong correlation with the severity of general symptoms during one of the two main emotional peaks (Spearman R = 0.77); and (b) k-mean clustering demonstrated that the networks’ NCI dynamic during the social-affective context reliably differentiated between patients and controls. Together, these findings point to a possible neural marker for abnormal social-affective processing in schizophrenia, manifested as the disturbed balance between two functional networks involved in social-affective affiliation. This in turn suggests that exaggerated mentalization over somatic-affiliative processing, in response to another’s’ distress may underlie social-affective deficits in schizophrenia. Nature Publishing Group UK 2018-01-31 /pmc/articles/PMC5802465/ /pubmed/29382814 http://dx.doi.org/10.1038/s41398-017-0055-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hendler, Talma
Raz, Gal
Shimrit, Solnik
Jacob, Yael
Lin, Tamar
Roseman, Leor
Wahid, Wahid Madah
Kremer, Ilana
Kupchik, Marina
Kotler, Moshe
Bleich-Cohen, Maya
Social affective context reveals altered network dynamics in schizophrenia patients
title Social affective context reveals altered network dynamics in schizophrenia patients
title_full Social affective context reveals altered network dynamics in schizophrenia patients
title_fullStr Social affective context reveals altered network dynamics in schizophrenia patients
title_full_unstemmed Social affective context reveals altered network dynamics in schizophrenia patients
title_short Social affective context reveals altered network dynamics in schizophrenia patients
title_sort social affective context reveals altered network dynamics in schizophrenia patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802465/
https://www.ncbi.nlm.nih.gov/pubmed/29382814
http://dx.doi.org/10.1038/s41398-017-0055-9
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