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Vitamin D and Breast Cancer: Latest Evidence and Future Steps
Vitamin D (the sunshine vitamin) plays a vital role in calcium homeostasis, skeletal metabolism, and immune, cardiovascular, and reproductive systems’ functions. The worldwide prevalence of vitamin D deficiency is approximately 1 billion. Vitamin D deficiency is a serious health problem with numerou...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802611/ https://www.ncbi.nlm.nih.gov/pubmed/29434472 http://dx.doi.org/10.1177/1178223417749816 |
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author | Atoum, Manar Alzoughool, Foad |
author_facet | Atoum, Manar Alzoughool, Foad |
author_sort | Atoum, Manar |
collection | PubMed |
description | Vitamin D (the sunshine vitamin) plays a vital role in calcium homeostasis, skeletal metabolism, and immune, cardiovascular, and reproductive systems’ functions. The worldwide prevalence of vitamin D deficiency is approximately 1 billion. Vitamin D deficiency is a serious health problem with numerous health consequences; it is associated with diabetes, rheumatic arthritis, Parkinson, Alzheimer diseases, osteomalacia, osteoporosis, and fractures in adults and cancers. Many reports showed an inverse association between serum vitamin D concentration and incidence of several cancers, including breast, colorectal, kidney, lung, and pancreatic. About 20 different cancers have incidence rates inversely related to solar UV-B doses and serum vitamin D concentration. Considering the rising incidence of breast cancer and high prevalence of vitamin D deficiency, this review aimed to reflect an association between serum vitamin D concentration and breast cancer risk, reveal the link between vitamin D receptor genetic polymorphisms and breast cancer risk, and review the relationship between vitamin D level, breast cancer risk, and prognostic factors such as tumor stage, grade, size, lymph node involvement, and hormone receptor status. |
format | Online Article Text |
id | pubmed-5802611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-58026112018-02-12 Vitamin D and Breast Cancer: Latest Evidence and Future Steps Atoum, Manar Alzoughool, Foad Breast Cancer (Auckl) Review Vitamin D (the sunshine vitamin) plays a vital role in calcium homeostasis, skeletal metabolism, and immune, cardiovascular, and reproductive systems’ functions. The worldwide prevalence of vitamin D deficiency is approximately 1 billion. Vitamin D deficiency is a serious health problem with numerous health consequences; it is associated with diabetes, rheumatic arthritis, Parkinson, Alzheimer diseases, osteomalacia, osteoporosis, and fractures in adults and cancers. Many reports showed an inverse association between serum vitamin D concentration and incidence of several cancers, including breast, colorectal, kidney, lung, and pancreatic. About 20 different cancers have incidence rates inversely related to solar UV-B doses and serum vitamin D concentration. Considering the rising incidence of breast cancer and high prevalence of vitamin D deficiency, this review aimed to reflect an association between serum vitamin D concentration and breast cancer risk, reveal the link between vitamin D receptor genetic polymorphisms and breast cancer risk, and review the relationship between vitamin D level, breast cancer risk, and prognostic factors such as tumor stage, grade, size, lymph node involvement, and hormone receptor status. SAGE Publications 2017-12-20 /pmc/articles/PMC5802611/ /pubmed/29434472 http://dx.doi.org/10.1177/1178223417749816 Text en © The Author(s) 2017 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Atoum, Manar Alzoughool, Foad Vitamin D and Breast Cancer: Latest Evidence and Future Steps |
title | Vitamin D and Breast Cancer: Latest Evidence and Future Steps |
title_full | Vitamin D and Breast Cancer: Latest Evidence and Future Steps |
title_fullStr | Vitamin D and Breast Cancer: Latest Evidence and Future Steps |
title_full_unstemmed | Vitamin D and Breast Cancer: Latest Evidence and Future Steps |
title_short | Vitamin D and Breast Cancer: Latest Evidence and Future Steps |
title_sort | vitamin d and breast cancer: latest evidence and future steps |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802611/ https://www.ncbi.nlm.nih.gov/pubmed/29434472 http://dx.doi.org/10.1177/1178223417749816 |
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