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Vitamin D and Breast Cancer: Latest Evidence and Future Steps

Vitamin D (the sunshine vitamin) plays a vital role in calcium homeostasis, skeletal metabolism, and immune, cardiovascular, and reproductive systems’ functions. The worldwide prevalence of vitamin D deficiency is approximately 1 billion. Vitamin D deficiency is a serious health problem with numerou...

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Detalles Bibliográficos
Autores principales: Atoum, Manar, Alzoughool, Foad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802611/
https://www.ncbi.nlm.nih.gov/pubmed/29434472
http://dx.doi.org/10.1177/1178223417749816
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author Atoum, Manar
Alzoughool, Foad
author_facet Atoum, Manar
Alzoughool, Foad
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description Vitamin D (the sunshine vitamin) plays a vital role in calcium homeostasis, skeletal metabolism, and immune, cardiovascular, and reproductive systems’ functions. The worldwide prevalence of vitamin D deficiency is approximately 1 billion. Vitamin D deficiency is a serious health problem with numerous health consequences; it is associated with diabetes, rheumatic arthritis, Parkinson, Alzheimer diseases, osteomalacia, osteoporosis, and fractures in adults and cancers. Many reports showed an inverse association between serum vitamin D concentration and incidence of several cancers, including breast, colorectal, kidney, lung, and pancreatic. About 20 different cancers have incidence rates inversely related to solar UV-B doses and serum vitamin D concentration. Considering the rising incidence of breast cancer and high prevalence of vitamin D deficiency, this review aimed to reflect an association between serum vitamin D concentration and breast cancer risk, reveal the link between vitamin D receptor genetic polymorphisms and breast cancer risk, and review the relationship between vitamin D level, breast cancer risk, and prognostic factors such as tumor stage, grade, size, lymph node involvement, and hormone receptor status.
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spelling pubmed-58026112018-02-12 Vitamin D and Breast Cancer: Latest Evidence and Future Steps Atoum, Manar Alzoughool, Foad Breast Cancer (Auckl) Review Vitamin D (the sunshine vitamin) plays a vital role in calcium homeostasis, skeletal metabolism, and immune, cardiovascular, and reproductive systems’ functions. The worldwide prevalence of vitamin D deficiency is approximately 1 billion. Vitamin D deficiency is a serious health problem with numerous health consequences; it is associated with diabetes, rheumatic arthritis, Parkinson, Alzheimer diseases, osteomalacia, osteoporosis, and fractures in adults and cancers. Many reports showed an inverse association between serum vitamin D concentration and incidence of several cancers, including breast, colorectal, kidney, lung, and pancreatic. About 20 different cancers have incidence rates inversely related to solar UV-B doses and serum vitamin D concentration. Considering the rising incidence of breast cancer and high prevalence of vitamin D deficiency, this review aimed to reflect an association between serum vitamin D concentration and breast cancer risk, reveal the link between vitamin D receptor genetic polymorphisms and breast cancer risk, and review the relationship between vitamin D level, breast cancer risk, and prognostic factors such as tumor stage, grade, size, lymph node involvement, and hormone receptor status. SAGE Publications 2017-12-20 /pmc/articles/PMC5802611/ /pubmed/29434472 http://dx.doi.org/10.1177/1178223417749816 Text en © The Author(s) 2017 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Atoum, Manar
Alzoughool, Foad
Vitamin D and Breast Cancer: Latest Evidence and Future Steps
title Vitamin D and Breast Cancer: Latest Evidence and Future Steps
title_full Vitamin D and Breast Cancer: Latest Evidence and Future Steps
title_fullStr Vitamin D and Breast Cancer: Latest Evidence and Future Steps
title_full_unstemmed Vitamin D and Breast Cancer: Latest Evidence and Future Steps
title_short Vitamin D and Breast Cancer: Latest Evidence and Future Steps
title_sort vitamin d and breast cancer: latest evidence and future steps
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802611/
https://www.ncbi.nlm.nih.gov/pubmed/29434472
http://dx.doi.org/10.1177/1178223417749816
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