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Use of electronic immunization registry in the surveillance of adverse events following immunization
OBJECTIVE: To describe adverse events following vaccination (AEFV) of children under two years old and analyze trend of this events from 2000 to 2013, in the city of Araraquara (SP), Brazil. METHODS: This is a descriptive study conducted with data of the passive surveillance system of AEFV that is a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Faculdade de Saúde Pública da Universidade de São Paulo
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802648/ https://www.ncbi.nlm.nih.gov/pubmed/29412373 http://dx.doi.org/10.11606/S1518-8787.2018052000295 |
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author | Sato, Ana Paula Sayuri Ferreira, Vinícius Leati de Rossi Tauil, Márcia de Cantuária Rodrigues, Laura Cunha Barros, Mariana Bernardes Martineli, Edmar Costa, Ângela Aparecida Inenami, Marta Waldman, Eliseu Alves |
author_facet | Sato, Ana Paula Sayuri Ferreira, Vinícius Leati de Rossi Tauil, Márcia de Cantuária Rodrigues, Laura Cunha Barros, Mariana Bernardes Martineli, Edmar Costa, Ângela Aparecida Inenami, Marta Waldman, Eliseu Alves |
author_sort | Sato, Ana Paula Sayuri |
collection | PubMed |
description | OBJECTIVE: To describe adverse events following vaccination (AEFV) of children under two years old and analyze trend of this events from 2000 to 2013, in the city of Araraquara (SP), Brazil. METHODS: This is a descriptive study conducted with data of the passive surveillance system of AEFV that is available in the electronic immunization registry (EIR) of the computerized medical record of the municipal health service (Juarez System). The study variables were: age, gender, vaccine, dose, clinical manifestations and hospitalization. We estimated rates using AEFV as numerator and administered doses of vaccines as denominator. The surveillance sensitivity was estimated by applying the method proposed by the Centers for Disease Control and Prevention. We used Prais-Winsten regression with a significance level of 5.0%. RESULTS: The average annual rate of AEFV was 11.3/10,000 administered doses, however without a trend in the study period (p=0.491). Most cases occurred after the first dose (41.7%) and among children under one year of age (72.6%). Vaccines with pertussis component, yellow fever and measles-mumps-rubella were the most reactogenic. We highlighted the rates of hypotonic-hyporesponsive episodes and convulsion that were 4.1/10,000 and 1.5/10,000 doses of vaccines with pertussis component, respectively, most frequently in the first dose; 60,0% of cases presented symptoms in the first 24 hours after vaccination, however, 18.6% showed after 96 hours. The sensitivity of surveillance was 71.9% and 78.9% for hypotonic-hyporesponsive episodes and convulsion, respectively. CONCLUSIONS: The EIR-based AEFV surveillance system proved to be useful and highly sensitive to describe the safety profile of vaccines in a medium-sized city. It was also shown that the significant increase of the vaccines included in the basic vaccination schedule in childhood in the last decade did not alter the high safety standard of the National Immunization Program. |
format | Online Article Text |
id | pubmed-5802648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Faculdade de Saúde Pública da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-58026482018-02-12 Use of electronic immunization registry in the surveillance of adverse events following immunization Sato, Ana Paula Sayuri Ferreira, Vinícius Leati de Rossi Tauil, Márcia de Cantuária Rodrigues, Laura Cunha Barros, Mariana Bernardes Martineli, Edmar Costa, Ângela Aparecida Inenami, Marta Waldman, Eliseu Alves Rev Saude Publica Original Articles OBJECTIVE: To describe adverse events following vaccination (AEFV) of children under two years old and analyze trend of this events from 2000 to 2013, in the city of Araraquara (SP), Brazil. METHODS: This is a descriptive study conducted with data of the passive surveillance system of AEFV that is available in the electronic immunization registry (EIR) of the computerized medical record of the municipal health service (Juarez System). The study variables were: age, gender, vaccine, dose, clinical manifestations and hospitalization. We estimated rates using AEFV as numerator and administered doses of vaccines as denominator. The surveillance sensitivity was estimated by applying the method proposed by the Centers for Disease Control and Prevention. We used Prais-Winsten regression with a significance level of 5.0%. RESULTS: The average annual rate of AEFV was 11.3/10,000 administered doses, however without a trend in the study period (p=0.491). Most cases occurred after the first dose (41.7%) and among children under one year of age (72.6%). Vaccines with pertussis component, yellow fever and measles-mumps-rubella were the most reactogenic. We highlighted the rates of hypotonic-hyporesponsive episodes and convulsion that were 4.1/10,000 and 1.5/10,000 doses of vaccines with pertussis component, respectively, most frequently in the first dose; 60,0% of cases presented symptoms in the first 24 hours after vaccination, however, 18.6% showed after 96 hours. The sensitivity of surveillance was 71.9% and 78.9% for hypotonic-hyporesponsive episodes and convulsion, respectively. CONCLUSIONS: The EIR-based AEFV surveillance system proved to be useful and highly sensitive to describe the safety profile of vaccines in a medium-sized city. It was also shown that the significant increase of the vaccines included in the basic vaccination schedule in childhood in the last decade did not alter the high safety standard of the National Immunization Program. Faculdade de Saúde Pública da Universidade de São Paulo 2018-01-29 /pmc/articles/PMC5802648/ /pubmed/29412373 http://dx.doi.org/10.11606/S1518-8787.2018052000295 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Sato, Ana Paula Sayuri Ferreira, Vinícius Leati de Rossi Tauil, Márcia de Cantuária Rodrigues, Laura Cunha Barros, Mariana Bernardes Martineli, Edmar Costa, Ângela Aparecida Inenami, Marta Waldman, Eliseu Alves Use of electronic immunization registry in the surveillance of adverse events following immunization |
title | Use of electronic immunization registry in the surveillance of adverse events following immunization |
title_full | Use of electronic immunization registry in the surveillance of adverse events following immunization |
title_fullStr | Use of electronic immunization registry in the surveillance of adverse events following immunization |
title_full_unstemmed | Use of electronic immunization registry in the surveillance of adverse events following immunization |
title_short | Use of electronic immunization registry in the surveillance of adverse events following immunization |
title_sort | use of electronic immunization registry in the surveillance of adverse events following immunization |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802648/ https://www.ncbi.nlm.nih.gov/pubmed/29412373 http://dx.doi.org/10.11606/S1518-8787.2018052000295 |
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