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Impact of liver volume on polycystic liver disease-related symptoms and quality of life
BACKGROUND: Symptoms in polycystic liver disease (PLD) are thought to be caused by compression of organs and structures by the enlarged liver. AIM: The aim of this article is to assess the impact of liver volume on symptoms and quality of life (QoL) in PLD. METHODS: We included PLD patients from two...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802666/ https://www.ncbi.nlm.nih.gov/pubmed/29435317 http://dx.doi.org/10.1177/2050640617705577 |
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author | Neijenhuis, Myrte K Kievit, Wietske Verheesen, Stef MH D’Agnolo, Hedwig M Gevers, Tom JG Drenth, Joost PH |
author_facet | Neijenhuis, Myrte K Kievit, Wietske Verheesen, Stef MH D’Agnolo, Hedwig M Gevers, Tom JG Drenth, Joost PH |
author_sort | Neijenhuis, Myrte K |
collection | PubMed |
description | BACKGROUND: Symptoms in polycystic liver disease (PLD) are thought to be caused by compression of organs and structures by the enlarged liver. AIM: The aim of this article is to assess the impact of liver volume on symptoms and quality of life (QoL) in PLD. METHODS: We included PLD patients from two prospective studies that used the PLD-questionnaire (PLD-Q) for symptom assessment. QoL was assessed through SF-36, summarized in a physical (PCS) and mental (MCS) component score. Liver volume was correlated with PLD-Q total scores. Patients were classified based on height-corrected liver volume in mild (<1600 ml), moderate (1600–3200 ml), and severe (>3200 ml) disease. PLD-Q and QoL (PCS and MCS) scores were compared across disease stages. RESULTS: We included 82 of 131 patients from the original studies (disease stages; mild n = 26, moderate n = 33, and severe n = 23). Patients with larger liver volume reported higher symptom burden (r = 0.516, p < 0.001). Symptom scores increased with disease progression, except for abdominal pain (p = 0.088). PCS decreased with advancing disease (p < 0.001), in contrast to MCS (p = 0.055). Moderate (p = 0.007) and severe (p < 0.001) PLD patients had lower PCS scores than the general population. CONCLUSION: PLD with larger liver volume is more likely to be symptomatic and is associated with lower QoL. |
format | Online Article Text |
id | pubmed-5802666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-58026662018-02-12 Impact of liver volume on polycystic liver disease-related symptoms and quality of life Neijenhuis, Myrte K Kievit, Wietske Verheesen, Stef MH D’Agnolo, Hedwig M Gevers, Tom JG Drenth, Joost PH United European Gastroenterol J Original Articles BACKGROUND: Symptoms in polycystic liver disease (PLD) are thought to be caused by compression of organs and structures by the enlarged liver. AIM: The aim of this article is to assess the impact of liver volume on symptoms and quality of life (QoL) in PLD. METHODS: We included PLD patients from two prospective studies that used the PLD-questionnaire (PLD-Q) for symptom assessment. QoL was assessed through SF-36, summarized in a physical (PCS) and mental (MCS) component score. Liver volume was correlated with PLD-Q total scores. Patients were classified based on height-corrected liver volume in mild (<1600 ml), moderate (1600–3200 ml), and severe (>3200 ml) disease. PLD-Q and QoL (PCS and MCS) scores were compared across disease stages. RESULTS: We included 82 of 131 patients from the original studies (disease stages; mild n = 26, moderate n = 33, and severe n = 23). Patients with larger liver volume reported higher symptom burden (r = 0.516, p < 0.001). Symptom scores increased with disease progression, except for abdominal pain (p = 0.088). PCS decreased with advancing disease (p < 0.001), in contrast to MCS (p = 0.055). Moderate (p = 0.007) and severe (p < 0.001) PLD patients had lower PCS scores than the general population. CONCLUSION: PLD with larger liver volume is more likely to be symptomatic and is associated with lower QoL. SAGE Publications 2017-04-13 2018-02 /pmc/articles/PMC5802666/ /pubmed/29435317 http://dx.doi.org/10.1177/2050640617705577 Text en © Author(s) 2017 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Articles Neijenhuis, Myrte K Kievit, Wietske Verheesen, Stef MH D’Agnolo, Hedwig M Gevers, Tom JG Drenth, Joost PH Impact of liver volume on polycystic liver disease-related symptoms and quality of life |
title | Impact of liver volume on polycystic liver disease-related symptoms and quality of life |
title_full | Impact of liver volume on polycystic liver disease-related symptoms and quality of life |
title_fullStr | Impact of liver volume on polycystic liver disease-related symptoms and quality of life |
title_full_unstemmed | Impact of liver volume on polycystic liver disease-related symptoms and quality of life |
title_short | Impact of liver volume on polycystic liver disease-related symptoms and quality of life |
title_sort | impact of liver volume on polycystic liver disease-related symptoms and quality of life |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802666/ https://www.ncbi.nlm.nih.gov/pubmed/29435317 http://dx.doi.org/10.1177/2050640617705577 |
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