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The constitutively active PKG II mutant effectively inhibits gastric cancer development via a blockade of EGF/EGFR-associated signalling cascades

Type II cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG II) is a membrane-anchored enzyme expressed mainly in the intestinal mucosa and the brain, and is associated with various physiological or pathological processes. Upregulation of PKG II is known to induce apoptosis and inhib...

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Detalles Bibliográficos
Autores principales:	Wu, Yan, Yuan, Miaomiao, Su, Wenbin, Zhu, Miaolin, Yao, Xiaoyuan, Wang, Ying, Qian, Hai, Jiang, Lu, Tao, Yan, Wu, Min, Pang, Ji, Chen, Yongchang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802699/ https://www.ncbi.nlm.nih.gov/pubmed/29434677 http://dx.doi.org/10.1177/1758834017751635

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