Cargando…

The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy

Neurodegenerative tauopathies are characterized by pathological accumulation of highly phosphorylated isoforms of tau protein, which leads to progressive neuronal loss. Neuroinflammation often accompanies tau-driven diseases; however, the direct role of neuroinflammation in tauopathies remains unkno...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vagnozzi, Alana N., Giannopoulos, Phillip F., Praticò, Domenico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802711/ https://www.ncbi.nlm.nih.gov/pubmed/29249809 http://dx.doi.org/10.1038/s41398-017-0017-2

Ejemplares similares

Brain 5‐lipoxygenase over‐expression worsens memory, synaptic integrity, and tau pathology in the P301S mice
por: Vagnozzi, Alana N., et al.
Publicado: (2017)

VPS35 regulates tau phosphorylation and neuropathology in tauopathy
por: Vagnozzi, Alana N., et al.
Publicado: (2021)

Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice
por: Giannopoulos, Phillip F., et al.
Publicado: (2018)

Glucose deficit triggers tau pathology and synaptic dysfunction in a tauopathy mouse model
por: Lauretti, E, et al.
Publicado: (2017)

Gene Knockout of 5-Lipoxygenase Rescues Synaptic Dysfunction and Improves Memory in the Triple-Transgenic Model of Alzheimer’s Disease
por: Giannopoulos, Phillip F., et al.
Publicado: (2013)

Elevated levels of brain homocysteine directly modulates the pathological phenotype of a mouse model of tauopathy
por: Di Meco, Antonio, et al.
Publicado: (2018)

The 5-Lipoxygenase as a Common Pathway for Pathological Brain and Vascular Aging
por: Chu, Jin, et al.
Publicado: (2009)

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice
por: Chu, Jin, et al.
Publicado: (2012)

Hippocampal Synaptic Alterations Associated with Tau Pathology in Primary Age-Related Tauopathy
por: Morris, Meaghan, et al.
Publicado: (2023)

Dissecting the Role of 5-Lipoxygenase in the Homocysteine-Induced Alzheimer’s Disease Pathology
por: Di Meco, Antonio, et al.
Publicado: (2018)

Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies
por: Akwa, Yvette, et al.
Publicado: (2022)

Endosomal sorting and trafficking, the retromer complex and neurodegeneration
por: Vagnozzi, Alana N., et al.
Publicado: (2018)

Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer’s disease mouse model
por: Chu, Jin, et al.
Publicado: (2012)

The Functional Role of microRNAs in the Pathogenesis of Tauopathy
por: Praticò, Domenico
Publicado: (2020)

Glial Tau Pathology in Tauopathies: Functional Consequences
por: Kahlson, Martha A., et al.
Publicado: (2016)

Seed-competent tau monomer initiates pathology in a tauopathy mouse model
por: Mirbaha, Hilda, et al.
Publicado: (2022)

PINK1 Alleviates Cognitive Impairments via Attenuating Pathological Tau Aggregation in a Mouse Model of Tauopathy
por: Jiang, Xing Jun, et al.
Publicado: (2022)

Truncated tau deregulates synaptic markers in rat model for human tauopathy
por: Jadhav, Santosh, et al.
Publicado: (2015)

Extra virgin olive oil improves synaptic activity, short‐term plasticity, memory, and neuropathology in a tauopathy model
por: Lauretti, Elisabetta, et al.
Publicado: (2019)

PET Imaging of Tau Pathology in Alzheimer’s Disease and Tauopathies
por: James, Olga G., et al.
Publicado: (2015)

The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer’s disease phenotype
por: Joshi, Yash B., et al.
Publicado: (2015)

Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy
por: Mate, Veronika, et al.
Publicado: (2022)

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models
por: Sankaranarayanan, Sethu, et al.
Publicado: (2015)

Knockout of 5-Lipoxygenase Results in Age-Dependent Anxiety-Like Behavior in Female Mice
por: Joshi, Yash B., et al.
Publicado: (2011)

A simple human cell model for TAU trafficking and tauopathy-related TAU pathology
por: Bell, Michael, et al.
Publicado: (2021)

Involvement of 5-Lipoxygenase in the Corticosteroid-Dependent Amyloid Beta Formation: In Vitro and In Vivo Evidence
por: Puccio, Simone, et al.
Publicado: (2011)

Zileuton Improves Memory Deficits, Amyloid and Tau Pathology in a Mouse Model of Alzheimer’s Disease with Plaques and Tangles
por: Chu, Jin, et al.
Publicado: (2013)

Analysis of in vivo turnover of tau in a mouse model of tauopathy
por: Yamada, Kaoru, et al.
Publicado: (2015)

Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy
por: Wang, Xiaohai, et al.
Publicado: (2018)

Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy
por: Fung, Christine W., et al.
Publicado: (2020)

Transcellular Spreading of Tau in Tauopathies
por: Demaegd, Koen, et al.
Publicado: (2018)

APOE ε2 is associated with increased tau pathology in primary tauopathy
por: Zhao, Na, et al.
Publicado: (2018)

Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies
por: Comerota, Michele M., et al.
Publicado: (2018)

Hyperphosphorylated Human Tau Accumulates at the Synapse, Localizing on Synaptic Mitochondrial Outer Membranes and Disrupting Respiration in a Mouse Model of Tauopathy
por: Trease, Andrew J., et al.
Publicado: (2022)

Association of Retromer Deficiency and Tau Pathology in Down Syndrome
por: Curtis, Mary Elizabeth, et al.
Publicado: (2022)

Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer’s phenotype
por: Li, Jian-Guo, et al.
Publicado: (2017)

Nmnat1 protects neuronal function without altering phospho‐tau pathology in a mouse model of tauopathy
por: Musiek, Erik S., et al.
Publicado: (2016)

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
por: Bemiller, Shane M., et al.
Publicado: (2017)

CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy
por: Joly-Amado, Aurelie, et al.
Publicado: (2020)

Numb regulates Tau levels and prevents neurodegeneration in tauopathy mouse models
por: Lacomme, Marine, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7i2pe6fikfjsrep4k25af9vm0u