Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe(2+)-binding

Collagen lysyl hydroxylases (LH1-3) are Fe(2+)- and 2-oxoglutarate (2-OG)-dependent oxygenases that maintain extracellular matrix homeostasis. High LH2 levels cause stable collagen cross-link accumulations that promote fibrosis and cancer progression. However, developing LH antagonists will require...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Hou-Fu, Tsai, Chi-Lin, Terajima, Masahiko, Tan, Xiaochao, Banerjee, Priyam, Miller, Mitchell D., Liu, Xin, Yu, Jiang, Byemerwa, Jovita, Alvarado, Sarah, Kaoud, Tamer S., Dalby, Kevin N., Bota-Rabassedas, Neus, Chen, Yulong, Yamauchi, Mitsuo, Tainer, John A., Phillips, George N., Kurie, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802723/
https://www.ncbi.nlm.nih.gov/pubmed/29410444
http://dx.doi.org/10.1038/s41467-018-02859-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802723/
https://www.ncbi.nlm.nih.gov/pubmed/29410444
http://dx.doi.org/10.1038/s41467-018-02859-z

Ejemplares similares