Cargando…

Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe(2+)-binding

Collagen lysyl hydroxylases (LH1-3) are Fe(2+)- and 2-oxoglutarate (2-OG)-dependent oxygenases that maintain extracellular matrix homeostasis. High LH2 levels cause stable collagen cross-link accumulations that promote fibrosis and cancer progression. However, developing LH antagonists will require...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Hou-Fu, Tsai, Chi-Lin, Terajima, Masahiko, Tan, Xiaochao, Banerjee, Priyam, Miller, Mitchell D., Liu, Xin, Yu, Jiang, Byemerwa, Jovita, Alvarado, Sarah, Kaoud, Tamer S., Dalby, Kevin N., Bota-Rabassedas, Neus, Chen, Yulong, Yamauchi, Mitsuo, Tainer, John A., Phillips, George N., Kurie, Jonathan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802723/ https://www.ncbi.nlm.nih.gov/pubmed/29410444 http://dx.doi.org/10.1038/s41467-018-02859-z

Ejemplares similares

Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe(2+)-binding
por: Guo, Hou-Fu, et al.
Publicado: (2018)

Use of osteoblast-derived matrix to assess the influence of collagen modifications on cancer cells
por: Bota-Rabassedas, Neus, et al.
Publicado: (2020)

FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch
por: Chen, Yulong, et al.
Publicado: (2017)

Lysyl hydroxylase 2 mediated collagen post-translational modifications and functional outcomes
por: Terajima, Masahiko, et al.
Publicado: (2022)

A collagen glucosyltransferase drives lung adenocarcinoma progression in mice
por: Guo, Hou-Fu, et al.
Publicado: (2021)

Lysyl hydroxylase 2-induced collagen cross-link switching promotes metastasis in head and neck squamous cell carcinomas
por: Sato, Kotaro, et al.
Publicado: (2021)

A matricellular protein fibulin-4 is essential for the activation of lysyl oxidase
por: Noda, Kazuo, et al.
Publicado: (2020)

Characterisation of the Drosophila procollagen lysyl hydroxylase, dPlod
por: Bunt, Stephanie, et al.
Publicado: (2011)

The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells
por: Banerjee, Priyam, et al.
Publicado: (2021)

Addiction to Golgi-resident PI4P synthesis in chromosome 1q21.3–amplified lung adenocarcinoma cells
por: Shi, Lei, et al.
Publicado: (2021)

Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases
por: Kamel, Marwa, et al.
Publicado: (2017)

Cancer becomes wasteful: emerging roles of exosomes(†) in cell-fate determination
por: Wendler, Franz, et al.
Publicado: (2013)

FGF coordinates air sac development by activation of the EGF ligand Vein through the transcription factor PntP2
por: Cruz, Josefa, et al.
Publicado: (2015)

Author Correction: FGF coordinates air sac development by activation of the EGF ligand Vein through the transcription factor PntP2
por: Cruz, Josefa, et al.
Publicado: (2022)

Erratum to “Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases”
por: Kamel, Marwa, et al.
Publicado: (2018)

Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
por: Scietti, Luigi, et al.
Publicado: (2018)

Pathology and Classification of SCLC
por: Raso, Maria Gabriela, et al.
Publicado: (2021)

The Activities of Lysyl Hydroxylase 3 (LH3) Regulate the Amount and Oligomerization Status of Adiponectin
por: Ruotsalainen, Heli, et al.
Publicado: (2012)

Lysyl Hydroxylase 3 Modifies Lysine Residues to Facilitate Oligomerization of Mannan-Binding Lectin
por: Risteli, Maija, et al.
Publicado: (2014)

Lysyl hydroxylases are transcription targets for GATA3 driving lung cancer cell metastasis
por: Liu, Wei, et al.
Publicado: (2018)

Author Correction: Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
por: Scietti, Luigi, et al.
Publicado: (2018)

Berberine Attenuates Cell Motility via Inhibiting Inflammation-Mediated Lysyl Hydroxylase-2 and Glycolysis
por: Du, Yishan, et al.
Publicado: (2022)

Thy-1(+) Cancer-associated Fibroblasts Adversely Impact Lung Cancer Prognosis
por: Schliekelman, Mark J., et al.
Publicado: (2017)

Pitx2 Regulates Procollagen Lysyl Hydroxylase (Plod) Gene Expression: Implications for the Pathology of Rieger Syndrome
por: Hjalt, Tord A., et al.
Publicado: (2001)

The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in the extracellular space are important for cell growth and viability
por: Wang, Chunguang, et al.
Publicado: (2009)

Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa
por: Watt, Stephen A., et al.
Publicado: (2015)

Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking
por: Gross, Stephen J., et al.
Publicado: (2021)

Correction to: Notch regulates vascular collagen IV basement membrane through modulation of lysyl hydroxylase 3 trafficking
por: Gross, Stephen J., et al.
Publicado: (2021)

Alfacalcidol enhances collagen quality in ovariectomized rat bones
por: Nagaoka, Hideaki, et al.
Publicado: (2014)

Adipocyte-derived IL-6 and leptin promote breast Cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression
por: He, Jin-Yong, et al.
Publicado: (2018)

Cerebral small vessel disease caused by PLOD3 mutation: Expanding the phenotypic spectrum of lysyl hydroxylase‐3 deficiency
por: Zhou, Ji, et al.
Publicado: (2022)

Phenylalanine Binding Is Linked to Dimerization of the Regulatory Domain of Phenylalanine Hydroxylase
por: Zhang, Shengnan, et al.
Publicado: (2014)

Stabilization of tryptophan hydroxylase 2 by l‐phenylalanine‐induced dimerization
por: Tidemand, Kasper D., et al.
Publicado: (2016)

Transcriptional control of a collagen deposition and adhesion process that promotes lung adenocarcinoma growth and metastasis
por: Tan, Xiaochao, et al.
Publicado: (2022)

Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)-induced dissecting abdominal aortic aneurysm
por: Li, Hao, et al.
Publicado: (2021)

A Fe(2+)-dependent self-inhibited state influences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes
por: Scietti, Luigi, et al.
Publicado: (2022)

Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network
por: Yang, Zihan, et al.
Publicado: (2023)

A Model of a MAPK•Substrate Complex in an Active Conformation: A Computational and Experimental Approach
por: Lee, Sunbae, et al.
Publicado: (2011)

Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2
por: Piserchio, Andrea, et al.
Publicado: (2015)

Erratum: Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2
por: Piserchio, Andrea, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hrlnq41glg75m23fqjcvq9on1j