The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity

Thalidomide was originally used as a sedative and found to be a teratogen, but now thalidomide and its derivatives are widely used to treat haematologic malignancies. Accumulated evidence suggests that thalidomide suppresses nerve cell death in neurologic model mice. However, detailed molecular mech...

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Detalles Bibliográficos
Autores principales: Sawamura, Naoya, Yamada, Mariko, Fujiwara, Miku, Yamada, Haruka, Hayashi, Hideki, Takagi, Norio, Asahi, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802741/
https://www.ncbi.nlm.nih.gov/pubmed/29410497
http://dx.doi.org/10.1038/s41598-018-20911-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802741/
https://www.ncbi.nlm.nih.gov/pubmed/29410497
http://dx.doi.org/10.1038/s41598-018-20911-2

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