Cargando…

The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity

Thalidomide was originally used as a sedative and found to be a teratogen, but now thalidomide and its derivatives are widely used to treat haematologic malignancies. Accumulated evidence suggests that thalidomide suppresses nerve cell death in neurologic model mice. However, detailed molecular mech...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sawamura, Naoya, Yamada, Mariko, Fujiwara, Miku, Yamada, Haruka, Hayashi, Hideki, Takagi, Norio, Asahi, Toru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802741/ https://www.ncbi.nlm.nih.gov/pubmed/29410497 http://dx.doi.org/10.1038/s41598-018-20911-2

Ejemplares similares

Structural basis of thalidomide enantiomer binding to cereblon
por: Mori, Tomoyuki, et al.
Publicado: (2018)

Mitochondrial cereblon functions as a Lon-type protease
por: Kataoka, Kosuke, et al.
Publicado: (2016)

Data for positive selection test and co-evolutionary analysis on mammalian cereblon
por: Onodera, Wataru, et al.
Publicado: (2019)

Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF
por: Yamanaka, Satoshi, et al.
Publicado: (2021)

CRL4-Cereblon complex in Thalidomide Embryopathy: a translational investigation
por: Kowalski, Thayne Woycinck, et al.
Publicado: (2020)

Antiangiogenic Activity and in Silico Cereblon Binding Analysis of Novel Thalidomide Analogs
por: Peach, Megan L., et al.
Publicado: (2020)

De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives
por: Heim, Christopher, et al.
Publicado: (2019)

Evaluation of the influence of genetic variants in Cereblon gene on the response to the treatment of erythema nodosum leprosum with thalidomide
por: Costa, Perpétua do Socorro Silva, et al.
Publicado: (2022)

Novel, thalidomide-like, non-cereblon binding drug tetrafluorobornylphthalimide mitigates inflammation and brain injury
por: Lecca, Daniela, et al.
Publicado: (2023)

The Thalidomide-Binding Domain of Cereblon Defines the CULT Domain Family and Is a New Member of the β-Tent Fold
por: Lupas, Andrei N., et al.
Publicado: (2015)

Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA
por: Yamada, Mariko, et al.
Publicado: (2019)

In silico analysis of enantioselective binding of immunomodulatory imide drugs to cereblon
por: Murai, Takahiro, et al.
Publicado: (2016)

Cholinergic receptor, nicotinic, alpha 7 as a target molecule of Arctic mutant amyloid β
por: Sawamura, Naoya, et al.
Publicado: (2018)

Rapid evolution of mammalian APLP1 as a synaptic adhesion molecule
por: Onodera, Wataru, et al.
Publicado: (2021)

Furin inhibitor protects against neuronal cell death induced by activated NMDA receptors
por: Yamada, Mariko, et al.
Publicado: (2018)

Chemical Ligand Space of Cereblon
por: Boichenko, Iuliia, et al.
Publicado: (2018)

Self-disproportionation of enantiomers of thalidomide and its fluorinated analogue via gravity-driven achiral chromatography: mechanistic rationale and implications
por: Maeno, Mayaka, et al.
Publicado: (2015)

Expression of cereblon protein assessed by immunohistochemicalstaining in myeloma cells is associated with superior response of thalidomide- and lenalidomide-based treatment, but not bortezomib-based treatment, in patients with multiple myeloma
por: Huang, Shang-Yi, et al.
Publicado: (2014)

Disruption of the Cereblon Gene Enhances Hepatic AMPK Activity and Prevents High-Fat Diet–Induced Obesity and Insulin Resistance in Mice
por: Lee, Kwang Min, et al.
Publicado: (2013)

Mouse Monoclonal Antibodies Generated from Full Length Human Cereblon: Detection of Cereblon Protein in Patients with Multiple Myeloma
por: Chang, Xiubao, et al.
Publicado: (2017)

Structural Dynamics of the Cereblon Ligand Binding Domain
por: Hartmann, Marcus D., et al.
Publicado: (2015)

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs
por: Gasic, Ivana, et al.
Publicado: (2020)

UDP-glucose, cereblon-dependent proinsulin degrader
por: Cho, Jaeyong, et al.
Publicado: (2022)

Data on the solution and processing time reached when constructing a phylogenetic tree using a quantum-inspired computer
por: Onodera, Wataru, et al.
Publicado: (2023)

Expression, mutation, and methylation of cereblon‐pathway genes at pre‐ and post‐lenalidomide treatment in multiple myeloma
por: Tachita, Takuto, et al.
Publicado: (2020)

Thalidomide for the Treatment of Refractory Multiple Myeloma: Association of Plasma Concentrations of Thalidomide and Angiogenic Growth Factors with Clinical Outcome
por: Kakimoto, Tsunayuki, et al.
Publicado: (2002)

Construction of photoenergetic mitochondria in cultured mammalian cells
por: Hara, Kiyotaka Y., et al.
Publicado: (2013)

Regulation of AMPK Activity by CRBN Is Independent of the Thalidomide-CRL4(CRBN) Protein Degradation Axis
por: Yang, Seung-Joo, et al.
Publicado: (2021)

Poly[(3-hexylthiophene)-block-(3-semifluoroalkylthiophene)] for Polymer Solar Cells
por: Yamada, Ichiko, et al.
Publicado: (2010)

Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation
por: Ando, Hideki, et al.
Publicado: (2019)

Thalidomide—Then and Now: Case Report of a Woman With Thalidomide Embryopathy and Review of Current Thalidomide Uses
por: Malik, Sara, et al.
Publicado: (2021)

Post-Injury Neuroprotective Effects of the Thalidomide Analog 3,6′-Dithiothalidomide on Traumatic Brain Injury
por: Batsaikhan, Buyandelger, et al.
Publicado: (2019)

Susceptibility of pentylenetetrazole-induced seizures in mice with Cereblon gene knockout
por: Jeon, Seung-Je, et al.
Publicado: (2020)

UDP-Glucose: A Cereblon-Dependent Glucokinase Protein Degrader
por: Cho, Jaeyong, et al.
Publicado: (2022)

Targeted protein degradation bypassing cereblon and von Hippel-Lindau
por: Lu, Wenchao
Publicado: (2023)

Rethinking thalidomide.
Publicado: (1995)

Thalidomide and neurotrophism
por: Soper, Judith R., et al.
Publicado: (2018)

Neuroprotective effect of cajaninstilbene acid against cerebral ischemia and reperfusion damages by activating AMPK/Nrf2 pathway
por: Xu, Hui, et al.
Publicado: (2020)

Involvement of Progranulin and Granulin Expression in Inflammatory Responses after Cerebral Ischemia
por: Horinokita, Ichiro, et al.
Publicado: (2019)

Understanding the Thalidomide Chirality in Biological Processes by the Self-disproportionation of Enantiomers
por: Tokunaga, Etsuko, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_es96hbu17velfgnds872fmjqah