Ischemia augments alloimmune injury through IL-6-driven CD4(+) alloreactivity

Ischemia reperfusion injuries (IRI) are unavoidable in solid organ transplantation. IRI augments alloimmunity but the mechanisms involved are poorly understood. Herein, we examined the effect of IRI on antigen specific alloimmunity. We demonstrate that ischemia promotes alloimmune activation, leadin...

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Detalles Bibliográficos
Autores principales: Uehara, Mayuko, Solhjou, Zhabiz, Banouni, Naima, Kasinath, Vivek, Xiaqun, Ye, Dai, Li, Yilmam, Osman, Yilmaz, Mine, Ichimura, Takaharu, Fiorina, Paolo, Martins, Paulo N., Ohori, Shunsuke, Guleria, Indira, Maarouf, Omar H., Tullius, Stefan G., McGrath, Martina M., Abdi, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802749/
https://www.ncbi.nlm.nih.gov/pubmed/29410442
http://dx.doi.org/10.1038/s41598-018-20858-4

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