A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense

Integrin-based therapeutics have garnered considerable interest in the medical treatment of inflammation. Integrins mediate the fast recruitment of monocytes and neutrophils to the site of inflammation, but are also required for host defense, limiting their therapeutic use. Here, we report a novel m...

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Detalles Bibliográficos
Autores principales: Wolf, Dennis, Anto-Michel, Nathaly, Blankenbach, Hermann, Wiedemann, Ansgar, Buscher, Konrad, Hohmann, Jan David, Lim, Bock, Bäuml, Marina, Marki, Alex, Mauler, Maximilian, Duerschmied, Daniel, Fan, Zhichao, Winkels, Holger, Sidler, Daniel, Diehl, Philipp, Zajonc, Dirk M, Hilgendorf, Ingo, Stachon, Peter, Marchini, Timoteo, Willecke, Florian, Schell, Maximilian, Sommer, Björn, von zur Muhlen, Constantin, Reinöhl, Jochen, Gerhardt, Teresa, Plow, Edward F., Yakubenko, Valentin, Libby, Peter, Bode, Christoph, Ley, Klaus, Peter, Karlheinz, Zirlik, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802769/
https://www.ncbi.nlm.nih.gov/pubmed/29410422
http://dx.doi.org/10.1038/s41467-018-02896-8

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