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Cryo-EM structure of 5-HT(3A) receptor in its resting conformation
Serotonin receptors (5-HT(3A)R) directly regulate gut movement, and drugs that inhibit 5-HT(3A)R function are used to control emetic reflexes associated with gastrointestinal pathologies and cancer therapies. The 5-HT(3A)R function involves a finely tuned orchestration of three domain movements that...
Autores principales: | Basak, Sandip, Gicheru, Yvonne, Samanta, Amrita, Molugu, Sudheer Kumar, Huang, Wei, Fuente, Maria la de, Hughes, Taylor, Taylor, Derek J., Nieman, Marvin T., Moiseenkova-Bell, Vera, Chakrapani, Sudha |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802770/ https://www.ncbi.nlm.nih.gov/pubmed/29410406 http://dx.doi.org/10.1038/s41467-018-02997-4 |
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