Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis

Enhanced glycolysis in cancer cells has been linked to cell protection from DNA damaging signals, although the mechanism is largely unknown. The 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) catalyzes the generation of fructose-2,6-bisphosphate, a potent allosteric stimulator of gly...

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Detalles Bibliográficos
Autores principales: Li, Fu-Long, Liu, Jin-Ping, Bao, Ruo-Xuan, Yan, GuoQuan, Feng, Xu, Xu, Yan-Ping, Sun, Yi-Ping, Yan, Weili, Ling, Zhi-Qiang, Xiong, Yue, Guan, Kun-Liang, Yuan, Hai-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802808/
https://www.ncbi.nlm.nih.gov/pubmed/29410405
http://dx.doi.org/10.1038/s41467-018-02950-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802808/
https://www.ncbi.nlm.nih.gov/pubmed/29410405
http://dx.doi.org/10.1038/s41467-018-02950-5

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