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Breast cancer risk factors and mammographic density among high-risk women in urban China
Elevated mammographic density (MD) is an established breast cancer risk factor. Studies examining relationships between MD and breast cancer risk factors are limited in China, where established breast cancer risk factors are less prevalent but dense breasts are more prevalent than Western countries....
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802809/ https://www.ncbi.nlm.nih.gov/pubmed/29423438 http://dx.doi.org/10.1038/s41523-018-0055-9 |
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author | Sung, Hyuna Ren, Jiansong Li, Jing Pfeiffer, Ruth M. Wang, Yong Guida, Jennifer L. Fang, Yi Shi, Jufang Zhang, Kai Li, Ni Wang, Shen Wei, Luopei Hu, Nan Gierach, Gretchen L. Dai, Min Yang, Xiaohong R. He, Jie |
author_facet | Sung, Hyuna Ren, Jiansong Li, Jing Pfeiffer, Ruth M. Wang, Yong Guida, Jennifer L. Fang, Yi Shi, Jufang Zhang, Kai Li, Ni Wang, Shen Wei, Luopei Hu, Nan Gierach, Gretchen L. Dai, Min Yang, Xiaohong R. He, Jie |
author_sort | Sung, Hyuna |
collection | PubMed |
description | Elevated mammographic density (MD) is an established breast cancer risk factor. Studies examining relationships between MD and breast cancer risk factors are limited in China, where established breast cancer risk factors are less prevalent but dense breasts are more prevalent than Western countries. This study included 11,478 women (45-69 years; 36% premenopausal) participating in an ongoing national cancer screening program in 11 urban provinces in China and predicted as having high-risk for breast cancer. Polytomous logistic regression was performed to assess associations between MD and risk factors by comparing each higher Breast Imaging Reporting and Data System (BI-RADS) category (2, 3, or 4) to the lowest category (BI-RADS, 1). We found associations of increasing age, body mass index, weight, postmenopausal status, and parity with lower MD. Higher levels of education, increasing height, and later first birth were associated with higher MD. These associations did not vary by menopausal status. Additionally, the association between longer period of breastfeeding and lower MD was seen among postmenopausal women only (P(interaction) = 0.003). Having first-degree relatives with breast cancer diagnosed before 50 years was associated with lower MD only among premenopausal women (P(interaction) = 0.061). We found effects of established breast cancer risk factors on MD showed similar directions in Chinese and Western women, supporting the hypothesis that MD represents cumulative exposure to breast cancer risk factors over the life course. Our findings help to understand the biological basis of the association of MD with breast cancer risk and have implications for breast cancer prevention research in China. |
format | Online Article Text |
id | pubmed-5802809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-58028092018-02-08 Breast cancer risk factors and mammographic density among high-risk women in urban China Sung, Hyuna Ren, Jiansong Li, Jing Pfeiffer, Ruth M. Wang, Yong Guida, Jennifer L. Fang, Yi Shi, Jufang Zhang, Kai Li, Ni Wang, Shen Wei, Luopei Hu, Nan Gierach, Gretchen L. Dai, Min Yang, Xiaohong R. He, Jie NPJ Breast Cancer Article Elevated mammographic density (MD) is an established breast cancer risk factor. Studies examining relationships between MD and breast cancer risk factors are limited in China, where established breast cancer risk factors are less prevalent but dense breasts are more prevalent than Western countries. This study included 11,478 women (45-69 years; 36% premenopausal) participating in an ongoing national cancer screening program in 11 urban provinces in China and predicted as having high-risk for breast cancer. Polytomous logistic regression was performed to assess associations between MD and risk factors by comparing each higher Breast Imaging Reporting and Data System (BI-RADS) category (2, 3, or 4) to the lowest category (BI-RADS, 1). We found associations of increasing age, body mass index, weight, postmenopausal status, and parity with lower MD. Higher levels of education, increasing height, and later first birth were associated with higher MD. These associations did not vary by menopausal status. Additionally, the association between longer period of breastfeeding and lower MD was seen among postmenopausal women only (P(interaction) = 0.003). Having first-degree relatives with breast cancer diagnosed before 50 years was associated with lower MD only among premenopausal women (P(interaction) = 0.061). We found effects of established breast cancer risk factors on MD showed similar directions in Chinese and Western women, supporting the hypothesis that MD represents cumulative exposure to breast cancer risk factors over the life course. Our findings help to understand the biological basis of the association of MD with breast cancer risk and have implications for breast cancer prevention research in China. Nature Publishing Group UK 2018-02-06 /pmc/articles/PMC5802809/ /pubmed/29423438 http://dx.doi.org/10.1038/s41523-018-0055-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Sung, Hyuna Ren, Jiansong Li, Jing Pfeiffer, Ruth M. Wang, Yong Guida, Jennifer L. Fang, Yi Shi, Jufang Zhang, Kai Li, Ni Wang, Shen Wei, Luopei Hu, Nan Gierach, Gretchen L. Dai, Min Yang, Xiaohong R. He, Jie Breast cancer risk factors and mammographic density among high-risk women in urban China |
title | Breast cancer risk factors and mammographic density among high-risk women in urban China |
title_full | Breast cancer risk factors and mammographic density among high-risk women in urban China |
title_fullStr | Breast cancer risk factors and mammographic density among high-risk women in urban China |
title_full_unstemmed | Breast cancer risk factors and mammographic density among high-risk women in urban China |
title_short | Breast cancer risk factors and mammographic density among high-risk women in urban China |
title_sort | breast cancer risk factors and mammographic density among high-risk women in urban china |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802809/ https://www.ncbi.nlm.nih.gov/pubmed/29423438 http://dx.doi.org/10.1038/s41523-018-0055-9 |
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