Heterologous Expression of a Novel Drug Transporter from the Malaria Parasite Alters Resistance to Quinoline Antimalarials

Antimalarial drug resistance hampers effective malaria treatment. Critical SNPs in a particular, putative amino acid transporter were recently linked to chloroquine (CQ) resistance in malaria parasites. Here, we show that this conserved protein (PF3D7_0629500 in Plasmodium falciparum; AAT1 in P. cha...

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Detalles Bibliográficos
Autores principales: Tindall, Sarah M., Vallières, Cindy, Lakhani, Dev H., Islahudin, Farida, Ting, Kang-Nee, Avery, Simon V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802821/
https://www.ncbi.nlm.nih.gov/pubmed/29410428
http://dx.doi.org/10.1038/s41598-018-20816-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802821/
https://www.ncbi.nlm.nih.gov/pubmed/29410428
http://dx.doi.org/10.1038/s41598-018-20816-0

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