Cargando…

Heterologous Expression of a Novel Drug Transporter from the Malaria Parasite Alters Resistance to Quinoline Antimalarials

Antimalarial drug resistance hampers effective malaria treatment. Critical SNPs in a particular, putative amino acid transporter were recently linked to chloroquine (CQ) resistance in malaria parasites. Here, we show that this conserved protein (PF3D7_0629500 in Plasmodium falciparum; AAT1 in P. cha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tindall, Sarah M., Vallières, Cindy, Lakhani, Dev H., Islahudin, Farida, Ting, Kang-Nee, Avery, Simon V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802821/ https://www.ncbi.nlm.nih.gov/pubmed/29410428 http://dx.doi.org/10.1038/s41598-018-20816-0

Ejemplares similares

The Candidate Antimalarial Drug MMV665909 Causes Oxygen-Dependent mRNA Mistranslation and Synergizes with Quinoline-Derived Antimalarials
por: Vallières, Cindy, et al.
Publicado: (2017)

The antimalarial drug quinine interferes with serotonin biosynthesis and action
por: Islahudin, Farida, et al.
Publicado: (2014)

The antimalarial drug primaquine targets Fe–S cluster proteins and yeast respiratory growth
por: Lalève, Anaïs, et al.
Publicado: (2015)

Quinoline-Based Hybrid Compounds with Antimalarial Activity
por: Nqoro, Xhamla, et al.
Publicado: (2017)

Quinoline Antimalarials Increase the Antibacterial Activity of Ampicillin
por: Olateju, Olajumoke A., et al.
Publicado: (2021)

Targeting malaria parasite invasion of red blood cells as an antimalarial strategy
por: Burns, Amy L, et al.
Publicado: (2019)

Structural modifications of quinoline-based antimalarial agents: Recent developments
por: Bawa, Sandhya, et al.
Publicado: (2010)

Synthesis and antimalarial potential of some novel quinoline-pyrazolopyridine derivatives
por: Saini, Deepika, et al.
Publicado: (2016)

A Review of Modifications of Quinoline Antimalarials: Mefloquine and (hydroxy)Chloroquine
por: Kucharski, Dawid J., et al.
Publicado: (2022)

Serine Proteases of Malaria Parasite Plasmodium falciparum: Potential as Antimalarial Drug Targets
por: Alam, Asrar
Publicado: (2014)

Transmission of Artemisinin-Resistant Malaria Parasites to Mosquitoes under Antimalarial Drug Pressure
por: Witmer, Kathrin, et al.
Publicado: (2020)

New Potential Antimalarial Agents: Design, Synthesis and Biological Evaluation of Some Novel Quinoline Derivatives as Antimalarial Agents
por: Radini, Ibrahim Ali M., et al.
Publicado: (2016)

Transfection of the Primate Malaria Parasite Plasmodium knowlesi Using Entirely Heterologous Constructs
por: van der Wel, Anna M., et al.
Publicado: (1997)

The arrhythmogenic cardiotoxicity of the quinoline and structurally related antimalarial drugs: a systematic review
por: Haeusler, Ilsa L., et al.
Publicado: (2018)

Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle
por: Favuzza, Paola, et al.
Publicado: (2020)

Antimalarial drug discovery against malaria parasites through haplopine modification: An advanced computational approach
por: Akash, Shopnil, et al.
Publicado: (2023)

The natural function of the malaria parasite’s chloroquine resistance transporter
por: Shafik, Sarah H., et al.
Publicado: (2020)

Interference with Hemozoin Formation Represents an Important Mechanism of Schistosomicidal Action of Antimalarial Quinoline Methanols
por: Corrêa Soares, Juliana B. R., et al.
Publicado: (2009)

Repurposing Quinoline and Artemisinin Antimalarials as Therapeutics for SARS-CoV-2: Rationale and Implications
por: Firestone, Tessa M., et al.
Publicado: (2021)

Residual Antimalarials in Malaria Patients from Tanzania – Implications on Drug Efficacy Assessment and Spread of Parasite Resistance
por: Hodel, Eva Maria, et al.
Publicado: (2009)

Diverse antimalarials from whole-cell phenotypic screens disrupt malaria parasite ion and volume homeostasis
por: Dennis, Adelaide S. M., et al.
Publicado: (2018)

Experimental malaria-associated acute kidney injury is independent of parasite sequestration and resolves upon antimalarial treatment
por: Possemiers, Hendrik, et al.
Publicado: (2022)

Antimalarials and the fight against malaria in Brazil
por: Carmargo, Luiz MA, et al.
Publicado: (2009)

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy
por: Baragaña, Beatriz, et al.
Publicado: (2016)

Studies on the Action of Antimalarial Remedies on Monkey Malaria: The Relationship between the Concentration of Atebrin in the Circulating Blood and Parasite Count
por: Chopra, R. N., et al.
Publicado: (1936)

Identification of Potential Antimalarial Drug Candidates Targeting Falcipain-2 Protein of Malaria Parasite—A Computational Strategy
por: Nema, Shrikant, et al.
Publicado: (2022)

Factors Affecting Primaquine Combination Treatment in Malaria Patients in Selangor, Malaysia
por: Ariffin, Norliza Mat, et al.
Publicado: (2017)

Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations
por: Vallières, Cindy, et al.
Publicado: (2021)

‘Manipulation’ without the parasite: altered feeding behaviour of mosquitoes is not dependent on infection with malaria parasites
por: Cator, Lauren J., et al.
Publicado: (2013)

Expanding the antimalarial toolkit: Targeting host–parasite interactions
por: Langhorne, Jean, et al.
Publicado: (2016)

Propensity of selecting mutant parasites for the antimalarial drug cabamiquine
por: Stadler, Eva, et al.
Publicado: (2023)

Complete abrogation of sporozoite-induced sterile immunity by blood stage parasites of homologous and heterologous malaria species
por: Inoue, Megumi, et al.
Publicado: (2010)

Mode of action of quinoline antimalarial drugs in red blood cells infected by Plasmodium falciparum revealed in vivo
por: Kapishnikov, Sergey, et al.
Publicado: (2019)

The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance
por: Murithi, James M., et al.
Publicado: (2022)

The impact of HIV-1 on the malaria parasite biomass in adults in sub-Saharan Africa contributes to the emergence of antimalarial drug resistance
por: Van geertruyden, Jean-Pierre, et al.
Publicado: (2008)

Na(+) Regulation in the Malaria Parasite Plasmodiumfalciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials
por: Spillman, Natalie J., et al.
Publicado: (2013)

A systematic review of published antimalarial clinical trials: parasite clearance of artemisinin-containing regimens in the treatment of uncomplicated malaria
por: Das, Debashish, et al.
Publicado: (2012)

Evidence for Reduced Malaria Parasite Population after Application of Population-Level Antimalarial Drug Strategies in Southern Province, Zambia
por: Daniels, Rachel F., et al.
Publicado: (2020)

Copper-transporting ATPase is important for malaria parasite fertility
por: Kenthirapalan, Sanketha, et al.
Publicado: (2014)

Transport mechanisms at the malaria parasite-host cell interface
por: Beck, Josh R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_pbjbe2in4lvet07d5kvbekra7l