The peroxisome proliferator-activated receptor agonist pioglitazone and 5-lipoxygenase inhibitor zileuton have no effect on lung inflammation in healthy volunteers by positron emission tomography in a single-blind placebo-controlled cohort study

BACKGROUND: Anti-inflammatory drug development efforts for lung disease have been hampered in part by the lack of noninvasive inflammation biomarkers and the limited ability of animal models to predict efficacy in humans. We used (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET...

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Detalles Bibliográficos
Autores principales: Chen, Delphine L., Huang, Howard J., Byers, Derek E., Shifren, Adrian, Belikoff, Bryan, Engle, Jacquelyn T., Arentson, Elizabeth, Kemp, Debra, Phillips, Sharon, Scherrer, David E., Fujiwara, Hideji, Spayd, Katherine J., Brooks, Frank J., Pierce, Richard A., Castro, Mario, Isakow, Warren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802889/
https://www.ncbi.nlm.nih.gov/pubmed/29414995
http://dx.doi.org/10.1371/journal.pone.0191783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802889/
https://www.ncbi.nlm.nih.gov/pubmed/29414995
http://dx.doi.org/10.1371/journal.pone.0191783

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