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A single β-octyl glucoside molecule induces HIV-1 Nef dimer formation in the absence of partner protein binding

The HIV-1 Nef accessory protein is essential for viral pathogenicity and AIDS progression. Nef forms complexes with multiple host cell factors to facilitate viral replication and promote immune escape of HIV-infected cells. Previous X-ray crystal structures demonstrate that Nef forms homodimers, the...

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Detalles Bibliográficos
Autores principales:	Wu, Mousheng, Alvarado, John J., Augelli-Szafran, Corinne E., Ptak, Roger G., Smithgall, Thomas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802939/ https://www.ncbi.nlm.nih.gov/pubmed/29415006 http://dx.doi.org/10.1371/journal.pone.0192512

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