SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters

Perturbations to mammalian SWI/SNF (BAF) complexes contribute to over 20% of human cancers, with driving roles first identified in malignant rhabdoid tumor (MRT), an aggressive pediatric cancer characterized by biallelic inactivation of the core BAF complex subunit SMARCB1 (BAF47). However, the mech...

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Detalles Bibliográficos
Autores principales: Nakayama, Robert T., Pulice, John L., Valencia, Alfredo M., McBride, Matthew J., McKenzie, Zachary M., Gillespie, Mark A., Ku, Wai Lim, Teng, Mingxiang, Cui, Kairong, Williams, Robert T., Cassel, Seth H., Qing, He, Widmer, Christian J., Demetri, George D., Irizarry, Rafael A., Zhao, Keji, JeffRanish, Kadoch, Cigall
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803080/
https://www.ncbi.nlm.nih.gov/pubmed/28945250
http://dx.doi.org/10.1038/ng.3958

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