Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

ABSTRACT: Six new triterpenoid saponins, aesculusosides A–F (1–6), together with 19 known ones, were isolated from the seeds of Aesculus chinensis. The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data. Some of the isolates were e...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Jin-Tang, Chen, Shi-Tao, Guo, Cong, Jiao, Meng-Jiao, Cui, Wen-Jin, Wang, Shu-Hui, Deng, Zhe, Chen, Chang, Chen, Sha, Zhang, Jun, Liu, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803144/
https://www.ncbi.nlm.nih.gov/pubmed/29285602
http://dx.doi.org/10.1007/s13659-017-0148-4
Descripción
Sumario:ABSTRACT: Six new triterpenoid saponins, aesculusosides A–F (1–6), together with 19 known ones, were isolated from the seeds of Aesculus chinensis. The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data. Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay, and compounds 15, 16, 19, and 23–25 exhibited inhibitory activities against MCF-7 with IC(50) values ranging from 7.1 to 31.3 μM. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-017-0148-4) contains supplementary material, which is available to authorized users.

Ejemplares similares