Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities

ABSTRACT: Six new triterpenoid saponins, aesculusosides A–F (1–6), together with 19 known ones, were isolated from the seeds of Aesculus chinensis. The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data. Some of the isolates were e...

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Autores principales: Cheng, Jin-Tang, Chen, Shi-Tao, Guo, Cong, Jiao, Meng-Jiao, Cui, Wen-Jin, Wang, Shu-Hui, Deng, Zhe, Chen, Chang, Chen, Sha, Zhang, Jun, Liu, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803144/
https://www.ncbi.nlm.nih.gov/pubmed/29285602
http://dx.doi.org/10.1007/s13659-017-0148-4
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author Cheng, Jin-Tang
Chen, Shi-Tao
Guo, Cong
Jiao, Meng-Jiao
Cui, Wen-Jin
Wang, Shu-Hui
Deng, Zhe
Chen, Chang
Chen, Sha
Zhang, Jun
Liu, An
author_facet Cheng, Jin-Tang
Chen, Shi-Tao
Guo, Cong
Jiao, Meng-Jiao
Cui, Wen-Jin
Wang, Shu-Hui
Deng, Zhe
Chen, Chang
Chen, Sha
Zhang, Jun
Liu, An
author_sort Cheng, Jin-Tang
collection PubMed
description ABSTRACT: Six new triterpenoid saponins, aesculusosides A–F (1–6), together with 19 known ones, were isolated from the seeds of Aesculus chinensis. The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data. Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay, and compounds 15, 16, 19, and 23–25 exhibited inhibitory activities against MCF-7 with IC(50) values ranging from 7.1 to 31.3 μM. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-017-0148-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-58031442018-02-15 Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities Cheng, Jin-Tang Chen, Shi-Tao Guo, Cong Jiao, Meng-Jiao Cui, Wen-Jin Wang, Shu-Hui Deng, Zhe Chen, Chang Chen, Sha Zhang, Jun Liu, An Nat Prod Bioprospect Original Article ABSTRACT: Six new triterpenoid saponins, aesculusosides A–F (1–6), together with 19 known ones, were isolated from the seeds of Aesculus chinensis. The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data. Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay, and compounds 15, 16, 19, and 23–25 exhibited inhibitory activities against MCF-7 with IC(50) values ranging from 7.1 to 31.3 μM. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-017-0148-4) contains supplementary material, which is available to authorized users. Springer Singapore 2017-12-29 /pmc/articles/PMC5803144/ /pubmed/29285602 http://dx.doi.org/10.1007/s13659-017-0148-4 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Cheng, Jin-Tang
Chen, Shi-Tao
Guo, Cong
Jiao, Meng-Jiao
Cui, Wen-Jin
Wang, Shu-Hui
Deng, Zhe
Chen, Chang
Chen, Sha
Zhang, Jun
Liu, An
Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities
title Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities
title_full Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities
title_fullStr Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities
title_full_unstemmed Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities
title_short Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities
title_sort triterpenoid saponins from the seeds of aesculus chinensis and their cytotoxicities
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803144/
https://www.ncbi.nlm.nih.gov/pubmed/29285602
http://dx.doi.org/10.1007/s13659-017-0148-4
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