Cannabinomimetric Lipids: From Natural Extract to Artificial Synthesis

Endocannabinoid system is related with various physiological and cognitive processes including fertility, pregnancy, during pre- and postnatal development, pain-sensation, mood, appetite, and memory. In the latest decades, an important milestone concerning the endocannabinoid system was the discovery of the existence of the cannabinoid receptors CB(1) and CB(2). Anandamide was the first reported endogenous metabolite, which adjusted the release of some neurotransmitters through binding to the CB(1) or CB(2) receptors. Then a series of cannabinomimetric lipids were extracted from marine organisms, which possessed similar structure with anandamide. This review will provide a short account about cannabinomimetric lipids for their extraction and synthesis.